Results 211 to 220 of about 458,546 (351)

Provision of human ocular tissue for biomedical research: trends, limitations, and potential solutions from an eye bank [PDF]

Megan M. W. Straiko, Mark S. Ellison, Corrina Patzer, Kody Westrick, Khoa D. Tran   +4 more
openalex   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Select gene mutations associated with survival outcomes in ER-positive ERBB2-negative early-stage invasive breast cancer: A single-institutional tissue bank study. [PDF]

Cancer Med
Kok VC, Huang TY, Hsu YC, Chang YC, Yang PS.   +4 more
europepmc   +1 more source

Clinical and research applications of a brain tumor tissue bank in the age of precision medicine. [PDF]

Per Med, 2019
Snyder J, Poisson LM, Noushmehr H, Castro AV, deCarvalho AC, Robin A, Mukherjee A, Lee I, Walbert T.   +8 more
europepmc   +1 more source

Tissue metabolism in the common shrew and the bank vole [PDF]

, 1974
E. Malzahn
openalex   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Decellularized cryopreserved human pericardium: a validation study towards tissue bank practice. [PDF]

Cell Tissue Bank
Montagner G, Barbazza A, Lugas AT, Terzini M, Serino G, Bignardi C, Cacciatore M, Vida VL, Padalino MA, Trojan D.   +9 more
europepmc   +1 more source

Implementation of the Single European Code in a Multi-Tissue Bank. [PDF]

Transfus Med Hemother, 2017
Schroeter J, Schulz T, Schroeter B, Fleischhauer K, Pruß A.   +4 more
europepmc   +1 more source

PO-01-190 META-ANALYSIS OF RNASEQ DATA FROM TWO LARGE ATRIAL TISSUE BANKS IDENTIFIES MORE THAN 8000 TRANSCRIPTS ASSOCIATED WITH AF AND SUGGESTS A PROMINENT ROLE FOR MITOCHONDRIAL PROCESSES AND ENERGY METABOLISM: THE CATCH ME AND RACE V CONSORTIA [PDF]

Aaron Isaacs, Joris Winters, Stef Zeemering, Michał Kawczyński, Martijn Gilbers, Bart Maesen, Jos G. Maessen, Elham Bidar, Bas J. Boukens, B J M Hermans, Arne van Hunnik, Barabara Casadei, Larissa Fabritz, Winnie Chua, Laura C. Sommerfeld, Eduard Guasch, Lluı́s Mont, Montserrat Batlle, Stéphane Hatem, Paulus Kirchhof, Reza Wakili, Moritz F. Sinner, Stefan Kääb, Sander Verheule, Isabelle C. Van Gelder, Michiel Rienstra, Monika Stoll, Ulrich Schotten   +27 more
openalex   +1 more source