Results 181 to 190 of about 34,845 (312)
Acute regulation of murine adipose tissue lipolysis and insulin resistance by the TGFβ superfamily protein GDF3. [PDF]
Kotikalapudi N+11 more
europepmc +1 more source
Pinosylvin Inhibits Inflammatory and Osteoclastogenesis via NLRP3 Inflammasome
Pinosylvin blocks LPS and RANKL induced NEK7/NLRP3 interaction, inhibiting NLRP3 inflammasome oligomerization and assembly, reducing IL‐1β maturation and GSDMD cleavage, and improving the inflammatory microenvironment and abnormal osteoclastogenesis. Abstract Pro‐inflammatory cytokines such as TNF, IL‐1, and IL‐6 trigger aberrant osteoclastogenesis and
Wei Zhang+13 more
wiley +1 more source
Phase II study of rucaparib and nivolumab in patients with leiomyosarcoma. [PDF]
Movva S+27 more
europepmc +1 more source
The Irisin/Ce‐MBGNs delivery system can slowly release myokine Irisin for vital pulp therapy. Irisin/Ce‐MBGNs can enhance mitochondrial function and promote the differentiation of inflammatory macrophages toward M2‐Mφ, thereby regulating the immune response mechanism of inflamed dental pulp.
Mingxin Wang+9 more
wiley +1 more source
Ethical considerations for advancing research using organoid models derived from the placenta. [PDF]
Schäffers OJM+3 more
europepmc +1 more source
Oral aspirin administration induces intestinal expansion of Lactobacillus murinus and Lactobacillus johnsonii, which suppresses the progression of atherosclerosis. This microbial expansion significantly enhances butyrate production by providing lactate as a metabolic substrate, thereby fostering the growth of butyrate‐producing bacteria. Butyrate plays
Rui Hua+15 more
wiley +1 more source
14 Validation of transport systems to ensure quality of tissue delivered to eye banks
Mark Eagle, Prof Paul Rooney
doaj +1 more source
Clinicopathological Correlations of Neurodegenerative Diseases in the National Brain Biobank of Korea. [PDF]
Jung YH+14 more
europepmc +1 more source
This study uncovers STAT6‐driven pulmonary fibrosis (PF) via suppression of PRKN‐mediated airway epithelial mitophagy, triggering mitochondrial dysfunction and ferroptosis. Rifabutin is identified as a potent STAT6 inhibitor that effectively reverses fibrotic progression. These findings reveal the STAT6‐PRKN axis as a pathogenic regulator and provide a
Youjing Yang+7 more
wiley +1 more source
Bridging minds: Participant perspectives on postmortem brain research and engagement. [PDF]
Inoue Y+4 more
europepmc +1 more source