Results 191 to 200 of about 34,845 (312)

The TET3/GATA6 Axis Drives Lipid Metabolism and Therapeutic Vulnerabilities in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
The DNA demethylase TET3 drives lipid metabolic reprogramming in pancreatic ductal adenocarcinoma via a non‐catalytic mechanism. TET3 recruits histone deacetylases to repress GATA6, sustaining lipogenic enzyme expression and ferroptosis resistance.
Shuai Liu, Shaobo Kang, Na Lin, Wenqi Zhang, Shiwen Wang, Yuqing Ren, Xiaofan Ding, Jianxiu Yu, Ruiyu Xie   +8 more
wiley   +1 more source

Large-scale high-density brain-wide neural recording in nonhuman primates. [PDF]

Nat Neurosci
Trautmann EM, Hesse JK, Stine GM, Xia R, Zhu S, O'Shea DJ, Karsh B, Colonell J, Lanfranchi FF, Vyas S, Zimnik A, Amematsro E, Steinemann NA, Wagenaar DA, Pachitariu M, Andrei A, Lopez CM, O'Callaghan J, Putzeys J, Raducanu BC, Welkenhuysen M, Churchland M, Moore T, Shadlen M, Shenoy K, Tsao D, Dutta B, Harris T.   +27 more
europepmc   +1 more source

Radiation sterilisation and tissue banking [PDF]

Cell and Tissue Banking, 2018
openaire   +3 more sources

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source

Effect of Demineralization Time on the Release of Bone Morphogenetic Protein in Indigenously Prepared Demineralized Freeze-Dried Bone Allografts: A Comparative In Vitro Study. [PDF]

Cureus
Ansari N, Faraz F, Lamba AK, Tandon S, Kamal Z, Madni ZK.   +5 more
europepmc   +1 more source

Impact of Formalin- and Cryofixation on Raman Spectra of Human Tissues and Strategies for Tumor Bank Inclusion [PDF]

Giulia Mirizzi, Finn Jelke, Michel Pilot, Karoline Klein, Gilbert Georg Klamminger, Jean‐Jacques Gérardy, Marily Theodoropoulou, Laurent Mombaerts, Andreas Husch, Michel Mittelbronn, Frank Hertel, Felix Bruno Kleine Borgmann   +11 more
openalex   +1 more source

Musculoskeletal Tissue Banking

Journal of the Korean Medical Association, 1999
openaire   +2 more sources

The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress

Advanced Science, EarlyView.
This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu, Yi Shi, Chao‐Hua Kong, Ai‐Qun Chen, Ying Kang, Jun‐Yan Kan, Xiao‐Min Jiang, Peng Chu, Dong‐Chen Wang, Yi‐Fei Lv, Zhi‐Yuan Qian, Zi‐Hao Jiang, Yun‐Wei Chen, Yue Sun, Rui‐Rui Chang, Wen‐Ying Zhou, Yue Gu, Jun‐Xia Zhang, Shao‐Liang Chen   +18 more
wiley   +1 more source

Paradigm Shift in Eye Banking: From Tissue Retrieval to Cellular Harvesting and Bioengineering. [PDF]

Cornea
Deshmukh R, Dua HS, Mehta JS, Vajpayee RB, Jhanji V, Basu S.   +5 more
europepmc   +1 more source

Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2+ Smooth Muscle Cells

Advanced Science, EarlyView.
Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen, Yujie Zhu, Xi Yang, JiangBin Wu, Keyuan Chen, Wuqing Huang, Lu Fang, Qi Zhang, Jie Chen, Jianing Gao, Huanhuan Cao, Meifang Wu, Zhihuang Qiu, Yuling Zhang, Yue Shen, Qiuyu Huang, Zhiyong Lin, Lemin Zheng, Liangwan Chen   +18 more
wiley   +1 more source