Results 191 to 200 of about 178,306 (353)

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Pena, Eren Diniz, Susanne Burkhardt, Anna‐Lena Schütz, Verena Gisa, Iga Grzadzielewska, Karl Toischer, Thor D. Stein, Jan Krzysztof Blusztajn, Ivana Delalle, Jelena Radulovic, Farahnaz Sananbenesi, Andre Fischer   +17 more
wiley   +1 more source

Evaluating ultrastructural preservation quality in banked brain tissue

Macy Garrood, Alicia Keberle, Allison Sowa, William G.M. Janssen, Emma L Thorn, Claudia De Sanctis, Kurt Farrell, John F. Crary, Andrew McKenzie   +8 more
openalex   +2 more sources

STAGES OF INNOVATIVE PRODUCT DEVELOPMENT: THE CASE OF THE LABORATORY «BIO-TISSUE BANK»

, 2013
И. А. Кирилова, M. A. Sadovoy, Valentina Podorozhnaya, Ekaterina Mamonova, Anatoly Aronov, NEVZ-CERAMIOCS CJSC Novosibirsk, Russia   +5 more
openalex   +1 more source

Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation

Advanced Science, EarlyView.
Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong, Aima Huang, Ziqing Zhao, Bikai Lai, Xin Pan, Huiyu Yang, Xiaohan Xu, Tianwei Wang, Fangchen Zhao, Zhimin Zhang, Yongbo Xue, Guanjun Deng, Wenbin Deng, Jianwei Chen   +13 more
wiley   +1 more source

Brain banks in Latin America: Infrastructure for diagnosis, research, and scientific equity in Mexico and the Caribbean. [PDF]

Alzheimers Dement
Luna-Viramontes NI, Morlett-Paredes A, Ordoñez-Lozano I, de la Cruz-López F, Gonzalez-Chavez VE, Vargas-Hernández G, Pérez-Pérez EG, Méndez-Llaca RE, Villanueva-Fierro I, Ortiz-Butron R, Hernandes-Alejandro M, Garcés-Ramírez L, Luna-Muñoz J.   +12 more
europepmc   +1 more source

Lung Tissue Banks for Gene Expression Studies [PDF]

, 2004
Carlyne D. Cool, Mark W. Geraci
openalex   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Clinical and Pathological Features of Cutaneous Burns Caused by Mobile Phone Charging Devices. [PDF]

Cureus
Choi S, Jung YW, Cho E, Oh BH.
europepmc   +1 more source

Risk assessment of brucellosis for tissues processed and archived at the marine environmental specimen bank

, 2017
Jennifer Ness, Amanda J Moors, Rebecca S. Pugh   +2 more
openalex   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source