Provision of human ocular tissue for biomedical research: trends, limitations, and potential solutions from an eye bank [PDF]
Megan M. W. Straiko +4 more
openalex +1 more source
Advanced Science, EarlyView.Hybrid FRET–BRET biosensors were developed to monitor RAF–KRAS interactions in living cells. These sensors enable real‐time visualization of interaction dynamics, quantitative spectral analysis, and validation of mutation‐selective inhibitors, providing a versatile platform for probing KRAS regulation and therapeutic responses. ABSTRACT The RAS–RAF–MEK–
Jeong‐Min Go +12 more
wiley +1 more source
X Ray Diffraction: An Approach to Structural Quality of Biological Preserved Tissues in Tissue Banks
, 2012 Héctor Pérez +9 more
openalex +2 more sources
Lipid‐Facilitated Opening of the ADAM10 Sheddase Revealed by Enhanced Sampling Simulations
Advanced Science, EarlyView.Phosphatidylserine acts as a lipid trigger to enhance activation of the sheddase ADAM10. By integrating fluorescence spectroscopy assays with enhanced sampling molecular dynamics simulations, this study shows that phosphatidylserine promotes ADAM10 catalytic activity along with expansion of its extracellular domains, enhancing accessibility to scaffold
Adrien Schahl +7 more
wiley +1 more source
De Novo Multi‐Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning
Advanced Science, EarlyView.Current AI‐driven peptide discovery often overlooks complex structural data. This study presents M3‐CAD, a generative pipeline that leverages 3D voxel coloring and a massive database of over 12 000 peptides to capture nuanced physicochemical contexts.
Xiaojuan Li +23 more
wiley +1 more source
Comparing the efficacy of two antibiotic cocktails in decontamination of cardiovascular tissues. [PDF]
Cell Tissue BankLevy A +11 more
europepmc +1 more source
Ontology-based, Tissue MicroArray oriented, image centered tissue bank [PDF]
, 2008 Federica Viti +5 more
openalex +1 more source
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
Advanced Science, EarlyView.The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
wiley +1 more source
Life stage-dependent RNA interference in the tropical rock lobster <i>Panulirus ornatus</i>: mechanistic insights from RNA-seq and functional studies. [PDF]
Mar Life Sci TechnolBanks TM +5 more
europepmc +1 more source