Results 221 to 230 of about 34,845 (312)
The international ancient Egyptian mummy tissue bank
, 1970 Patricia I. Lambert-Zuzulak
openalex +2 more sources
Advanced Science, EarlyView.NPR1 induces lipolysis of stored lipid droplet and enhances mitochondrial oxidative phosphorylation to fuel gastric cancer metastasis. Specifically, NPR1‐mediated activation of PKG directly phosphorylates and activates HSL at Ser855 and Ser951, thereby driving lipolytic processes.
Huafeng Fu +15 more
wiley +1 more source
A Machine‐Learning Approach Identifies Rejuvenating Interventions in the Human Brain
Advanced Science, EarlyView.Rising life expectancy increases the incidence of age‐related neurodegeneration. Reverting brain aging through effective rejuvenation strategies constitutes a promising strategy to counteract these disorders and restore brain function. This study uses a brain‐specific transcriptional aging clock to screen over 43 000 perturbation profiles, identifying ...
Guillem Santamaria +5 more
wiley +1 more source
Foreword: Festschrift in honor of JM Krueger's research. [PDF]
Neurobiol Sleep Circadian RhythmsOpp MR, Rowe RK, Van Dongen HPA.
europepmc +1 more source
Advanced Science, EarlyView.SUMOylation regulates mitochondrial processes, but its impact on protein import remains unclear. TOM40 is identified, a mitochondrial outer membrane channel protein, as a substrate of deSUMOylase SENP6. TOM40 SUMOylation disrupts outer membrane complex assembly, inhibits protein import, and compromises mitochondrial homeostasis.
Liubing Hu +13 more
wiley +1 more source
Unveiling tissue-specific transcriptional adaptations in iPSC-derived fibroblasts via co-culture systems. [PDF]
Stem Cell Res TherAzad AJ +7 more
europepmc +1 more source
Advanced Science, EarlyView.Inducing ferroptosis is a promising strategy for combating tumor resistance. Upregulated PIP5K1A competes with NRF2 for KEAP1 binding, which decreases the ubiquitination degradation of NRF2 and promotes its nuclear translocation, thereby suppressing ferroptosis, and ultimately driving hepatocellular carcinoma (HCC) tumorigeneses and sorafenib ...
Mengzhou Guo +9 more
wiley +1 more source
Emerging approaches for ocular surface and corneal stromal regeneration: Recent advances and future perspectives. [PDF]
Indian J OphthalmolDeshmukh R, Joshi V, Singh V, Basu S.
europepmc +1 more source
Near‐Freezing‐Temperature Golgi Neuronal Staining for X‐ray Imaging of Human Brain
Advanced Science, EarlyView.A near‐freezing temperature staining strategy, combined with a mercury chloride‐based method, effectively preserves delicate neuronal structures in post‐mortem frozen human brain tissues by minimizing autolysis. This approach enables uniform labeling across centimeter‐scale slices and, when integrated with synchrotron‐based X‐ray microscopy, achieves ...
Feng Zhou +12 more
wiley +1 more source