Results 31 to 40 of about 405,445 (304)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Effect of gamma irradiation on proliferation and growth of friable embryogenic callus and in vitro nodal cuttings of ugandan cassava genotypes

Frontiers in Plant Science
Cassava (Manihot esculenta Crantz) production and productivity in Africa is affected by two viral diseases; cassava mosaic disease (CMD) and cassava brown streak disease (CBSD).
Hellen B. Apio, Wilfred Elegba, Wonder Nunekpeku, Solomon Ayeboafo Otu, Julius Karubanga Baguma, Titus Alicai, Kenneth Ellis Danso, Kenneth Ellis Danso, Isaac Kofi Bimpong, Emmanuel Ogwok, Emmanuel Ogwok   +10 more
doaj   +1 more source

Accelerated Dragon Fruit Production through Integrated Tissue Culture and Micro-Grafting Techniques. [PDF]

Horticulture Research Journal
Dragon fruit (Hylocereus spp.) is a high value crop crucial for meeting rising global demand; however, its commercial expansion is hampered by slow propagation, high pathogen susceptibility, and abiotic stresses such as drought and salinity.
Rania A.E. Abdelzaher, Said A. Nassar, Emad. M. Ashmawy, Wagner A. Vendrame   +3 more
doaj   +1 more source

Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes [PDF]

, 2011
The discovery of substantial amounts of 5-hydroxymethylcytosine (5hmC), formed by the oxidation of 5-methylcytosine (5mC), in various mouse tissues and human embryonic stem (ES) cells has necessitated a reevaluation of our knowledge of 5mC/5hmC patterns ...
Sproul, Duncan, Richard R. Meehan, Katz, Elad,, Nestor, Colm E., Meehan, Richard R,, Elad Katz, Dixon, J Michael,, Harrison, David James, Dixon, J. Michael, Raffaele Ottaviano, Dunican, Donncha, Sproul, Duncan,, Colm E. Nestor, Meehan, Richard R, Dunican, Donncha,, Nestor, Colm,, Reddington, James,, Duncan Sproul, David J. Harrison, Nestor, Colm E, Dunican, Donncha; id_orcid, Harrison, David J, James Reddington, Donncha Dunican, Reddington, James, Reinhardt, Diana,, J. Michael Dixon, Ottaviano, Raffaele,, Katz, Elad, Ottaviano, Raffaele, Dixon, J Michael, Meehan, Richard R., Reinhardt, Diana, Diana Reinhardt, Harrison, David J,   +34 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Tissue culture of Phalaenopsis: present status and future prospects

Journal of Advanced Biotechnology and Experimental Therapeutics, 2020
Phalaenopsis one of the popular cut-flower among the orchid species. The improvement/multiplication of this orchid is very difficult through conventional breeding due to delay flowering and uneven flower characteristics.
Khadiza Khatun, Ujjal Kumar Nath, Md. Shafikur Rahman   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Human Skin as an Ex Vivo Model for Maintaining Mycobacterium leprae and Leprosy Studies

Tropical Medicine and Infectious Disease
The in vitro cultivation of M. leprae has not been possible since it was described as causing leprosy, and the limitation of animal models for clinical aspects makes studies on leprosy and bacteria–human host interaction a challenge.
Natália Aparecida de Paula, Marcel Nani Leite, Daniele Ferreira de Faria Bertoluci, Cleverson Teixeira Soares, Patrícia Sammarco Rosa, Marco Andrey Cipriani Frade   +5 more
doaj   +1 more source