Results 61 to 70 of about 10,801,888 (291)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Orthopaedic Surgery, 2020 Objective To compare the ability of three culture strategies of static culture, intermittent centrifugal culture and dynamic bioreactor culture in promoting the infiltration of bone marrow mesenchymal stem cells (BMSCs) throughout electrospun nanoporous ...
Shuang Wang +5 more
doaj +1 more source
Development of tetraploids in tissue culture: modern techniques and biotechnological innovations
Polyploidy, characterized by chromosome multiplication, plays a pivotal role in plant evolution and agricultural innovation. This review explores advanced methodologies for tetraploid development in tissue culture, highlighting chemical inducers such as ...
Mohamed, Heba I. +6 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
, 1973 A presentation slide reflecting a list of Tissue Culture and Cells, and labeled Life Science Flight Research Approach, Tissue Culture and ...
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Mutation induction and tissue culture in improving fruits
, 2001 This review describes in vitro mutation induction methods in fruits and the in vitro selection procedures available for early screening. Results obtained through in vitro mutation techniques, including somaclonal variation, are reviewed and compared with
Predieri S
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Key Techniques in Tissue Culture of Scape Explants from Hemerocallis citrina
PlantsDatong in Shanxi Province, known as the “Daylily Capital of China,” still primarily relies on traditional propagation by division for daylily seedling production. Although traditional seedling propagation methods are simple and low-cost, they suffer from
Ying Wang +3 more
doaj +1 more source
Potential of tissue cultured medicinal plants in Malaysia [PDF]
, 2013 Medicinal plants possess many secondary products that exhibit biological activities such as antioxidant, anticancer, anti-inflammatory, antibacterial and anti microbial.
Abd Samad, Azman +2 more
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