Results 101 to 110 of about 2,261,601 (352)

Mesenchymal stem cell-derived extracellular vesicles attenuate periductal fibrosis by inhibiting Th17 differentiation in human liver multilineage organoids and Mdr2−/− mice

Journal of Nanobiotechnology
Primary sclerosing cholangitis (PSC) pathogenesis involves immune dysregulation, genetic factors, and bile duct pathology; however, a comprehensive pathogenesis model and effective therapeutic strategies remain limited.
Wenyi Chen, Xinyi Chen, Feiqiong Gao, Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Jinfeng Yang, Guanghua Ma, Jintao Gong, Qian Li, Yunhua Chen, Lee Wei Lim, Ilia Stambler, Georgina M. Ellison-Hughes, Brun Ulfhake, Robert Chunhua Zhao, Hongcui Cao   +17 more
doaj   +1 more source

Survey of the initial management of celiac disease antibody tests by ordering physicians

BMC Pediatrics, 2019
Background Appropriate interpretation of a positive celiac antibody test by an ordering physician is important in order to institute proper management.
Kathryn Potter, Lawrence de Koning, J. Decker Butzner, Dominica Gidrewicz   +3 more
doaj   +1 more source

Molecular pathology assists the diagnosis of lymphoepithelial sialadenitis, Sjögren's syndrome and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue

, 2023
Yanting Chi, Q M Zhang, Zhiming Qin, Jiaying Bai, Jing Yan, Cuiling Liu, Binbin Li   +6 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Mixed connective tissue disease: Not always an obvious diagnosis

Clinical Case Reports, 2020
Mixed connective tissue disease (MCTD) is characterized by a mixture of clinical features. The initial presentation is often incomplete, and the features of MCTD usually develop as the disease evolves.
Safa Rahmouni, Kaouther Maatallah, Hanene Ferjani, Leila Abid, Dhia Kaffel, Wafa Hamdi   +5 more
doaj   +1 more source

Capillaroscopy as a diagnostic tool in the diagnosis of mixed connective tissue disease (MCTD): a case report [PDF]

, 2021
Mislav Radić, Rebecca S. Overbury
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Dependence of the clinical course of generalized periodontitis on the quality of occlusal balance after complex treatment.

Medičnì Perspektivi, 2019
The purpose of this research was to study the features of the clinical course of generalized periodontitis, depending on the quality of occlusal balance after complex treatment.
V. G. Malynovskyi
doaj   +1 more source

The symptomatology of aneurysmal bone cyst : the value of diagnostic imaging [PDF]

, 2009
Background: An aneurysmal bone cyst (ABC) is a benign lesion occurring mainly in children. Generally it is found in the metaphyses of long bones and in flat bones.
Bekiesińska-Figatowska, Monika, Brągoszewska, Hanna, Iwanowska, Beata, Klepacka, Teresa, Kopyś-Wiszniewska, Izabela, Kowalska, Barbara, Koziarska, Teresa, Romaniuk-Doroszewska, Anna, Rychłowska-Pruszyńska, Magdalena, Uliasz, Maria   +9 more
core  

Asbestos exposure diagnosis in pulmonary tissues

Pathologica
The diagnosis of asbestosis requires different criteria depending on whether it is in a clinical or medical/legal setting. In the latter context, only when a "diffuse interstitial fibrosis associated to asbestos bodies (ABs)" is present, it can be said to be asbestosis.
Bellis, Donata, Croce, Alessandro, Glorioso, Alex, Bertolotti, Marinella, Maconi, Antonio   +4 more
openaire   +3 more sources