Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Articular chondrocytes isolated from the knee and ankle joints of human tissue donors demonstrate similar redox-regulated MAP kinase and Akt signaling. [PDF]
Osteoarthritis Cartilage, 2019 Collins JA +3 more
europepmc +1 more source
Characterizing Donor-Derived Cells in Nonhematopoietic Tissue
Biology of Blood and Marrow Transplantation, 2006 Beverly Torok-Storb +2 more
openaire +3 more sources
Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation
Molecular Oncology, EarlyView.Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza +5 more
wiley +1 more source
The Major Histocompatibility Complex (MHC) of the Secondary Transplant Tissue Donor Influences the Cross‐Reactivity of Alloreactive Memory Cells [PDF]
, 2010 Wang Fu-ming +10 more
openalex +1 more source
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban +12 more
wiley +1 more source
Space, place and temporality in stem cell and cancer tissue banking: Mediating between patient-donors and biomedical research [PDF]
, 2012 Neil Stephens
openalex +1 more source
Donor pretreatment with FLT-3 ligand augments anti-donor CTL, NK and LAK cell activities within liver allografts and alters the pattern of intragraft apoptotic activity [PDF]
, 1998 Chambers, FG +9 more
core
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source