Results 151 to 160 of about 445,327 (340)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Effect of Low Dose Dopamine on Early Graft Function in Living Unrelated Kidney Donors

Urology Journal, 2012
Purpose: To evaluate the effect of low-dose dopamine administration on the early function of the kidney in unrelated kidney donors after transplantation.Materials and Methods: In this double-blinded clinical trial, 60 adult kidney donors and 60 ...
Parisa Hosseinzadeh, Afshar Zomorrodi, Davood Aghamohammadi, Ata Mahmoodpoor, Mohammad Abravesh, Samad Golzari, Hamzeh Hosseinzadeh   +6 more
doaj  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Interspecies reactivity and intraspecies specificity of antilymphoid globulin [PDF]

, 1967
Horse antihuman and antidog antilymphocyte globulins were shown to possess leukoagglutinating antibodies when tested against the white cells from a number of other divergent species.
Iwasaki, Y, Kashiwagi, N, Marchioro, TL, Putnam, CW, Starzl, TE, Terasaki, PI   +5 more
core  

Human Ganglia and Spinal Cord Tissue Procurement from Organ Donors and Tissue Quality Assessment v1 [PDF]

Stephanie Shiers, Muhammad Saad Yousuf, Juliet M. Mwirigi, Anna Cervantes, Theodore J. Price   +4 more
openalex   +1 more source

Case Report and Literature Review of the Sequential Treatment Involving Percutaneous Transluminal Angioplasty (PTA), Tissue-engineered Skin Graft (ADM), Autologous Skin Graft and Negative Pressure Wound Therapy (NPWT) in Chronic Limb-threatening Ischemia (CLTI) Patients with Extensive Ulcers in the Donor Site after Coronary Artery Bypass Graft Surgery [PDF]

, 2022
Jin‐Jun Wang, Xianming Huang, Pinyi Wang, Linru Wang, Juanzi Zhang, Qiuxia Liu, Diyu Geng, Wenwen Li, Xiguang Chen   +8 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Positive toxicology and reactive serology in tissue donors: a retrospective study over a 3-year period. [PDF]

Cell Tissue Bank, 2020
Heck E, Gruslin K, Corder V, Petroll WM, Urban J.   +4 more
europepmc   +1 more source

The American Association of Tissue Banks tissue donor screening for Mycobacterium tuberculosis—Recommended criteria and literature review [PDF]

Melissa A. Greenwald, Noelle Edwards, D. Ted Eastlund, Inga Gurevich, Andrea Pervine‐Zaman Ho, Ghada Khalife, Janet Lin‐Torre, Hannis W. Thompson, Ross M. Wilkins, Sally Alrabaa   +9 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source