Results 181 to 190 of about 127,036 (216)

From Isolated to Complex: Diagnostic Yield of Chromosomal Microarray and Exome Sequencing in Fetal Growth Restriction

open access: yesPrenatal Diagnosis, EarlyView.
ABSTRACT Objective To characterize the overall diagnostic yield of sequential chromosomal microarray (CMA) and exome sequencing (ES) across the phenotypic spectrum of fetal growth restriction (FGR). Methods A retrospective cohort of 320 consecutive FGR pregnancies presenting at ≥ 20 weeks to a tertiary fetal medicine unit (2020–2025).
Hadas Miremberg   +11 more
wiley   +1 more source

Transplacental Flecainide and/or Digoxin for Fetal Tachyarrhythmias: Therapeutic Efficacy and Clinical Experience

open access: yesPrenatal Diagnosis, EarlyView.
ABSTRACT Objective To assess the efficacy and safety of transplacental flecainide and/or digoxin for fetal tachyarrhythmias when sotalol is unavailable. Method We evaluated transplacental flecainide, digoxin, or combination therapy in a retrospective and prospective cohort across two Thai tertiary centers.
Mukpradab Darakamas   +6 more
wiley   +1 more source

Diagnosis of Portal Hypertension: Advancing Towards Non‐Invasive Solutions

open access: yesPortal Hypertension &Cirrhosis, EarlyView.
This review systematically summarizes a full spectrum of non‐invasive diagnostic approaches for portal hypertension (PH), including imaging modalities, elastography, serum biomarkers, composite scoring systems and endoscopic ultrasound‐guided portal pressure gradient (EUS‐PPG), and analyzes their performance across different liver disease etiologies ...
Lijia Yin, Huikuan Chu, Ling Yang
wiley   +1 more source

Gentiopicroside Regulates EGFR and Induces Its Lysosomal Degradation to Attenuate Heart Failure

open access: yesPhytotherapy Research, EarlyView.
GPS attenuates pressure overload‐induced cardiac remodeling by promoting lysosomal degradation of EGFR. TAC‐induced EGFR accumulation activates AKT/ERK1/2 signaling and drives pathological cardiac hypertrophy, fibrosis, apoptosis, oxidative stress, and cardiac dysfunction. GPS promotes lysosome‐dependent EGFR degradation, thereby limiting excessive AKT/
Mingzhen Cao   +6 more
wiley   +1 more source

Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: A systematic review

open access: yesRheumatology &Autoimmunity, EarlyView.
This review integrates clinical, immunological, genetic, and multi‐omic evidence, highlighting dynamic inflammatory and adenosine‐pathway biomarkers and reinforcing treat‐to‐target principles as the most actionable framework for personalized methotrexate therapy.
Joana Ramos Rodrigues   +6 more
wiley   +1 more source

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