Results 21 to 30 of about 127,036 (216)

Subclinical Cardiac Dysfunction in Childhood Cancer Survivors on 10-Years Follow-Up Correlates With Cumulative Anthracycline Dose and Is Best Detected by Cardiopulmonary Exercise Testing, Circulating Serum Biomarker, Speckle Tracking Echocardiography, and Tissue Doppler Imaging

Frontiers in Pediatrics, 2020
Background: Survivors of childhood cancer are at risk for anthracycline- and/or radiotherapy-induced cardiotoxicity.Aims: The aim of this study was to assess clinical, laboratory, and imaging parameters of subclinical cardiovascular disease in childhood ...
Cordula Maria Wolf, Barbara Reiner, Barbara Reiner, Andreas Kühn, Alfred Hager, Jan Müller, Jan Müller, Christian Meierhofer, Renate Oberhoffer, Renate Oberhoffer, Peter Ewert, Irene Schmid, Jochen Weil   +12 more
doaj   +1 more source

Myocardial dyssynchrony, heart failure aetiology, and QRS complex duration in patients with clinically manifested chronic heart failure

Российский кардиологический журнал, 2013
Aim. To assess the prevalence and clinical value of various types of left ventricular (LV) myocardial dyssynchrony in patients with systolic chronic heart failure (CHF). Material and methods. In total, 71 patients with Functional Class (FC) II–IV CHF (LV
M. A. Trukhshina, M. Yu. Sitnikova
doaj   +1 more source

Features of remodeling of right heart chambers according to tissue Doppler and its correlation with cardiac rhythm disturbance in patients with COPD 2-3 severity

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2014
The article presents the study of early sings of dysfunction of right and left chambers of heart in patients with COPD 2 - 3 severity, correlation between structural and electrical remodeling of heart according to the stages of pulmonary hypertension ...
O. A. Zhuk, V. E. Perley, A. Y. Gichkin, A. L. Alexandrov, O. N. Titova, N. A. Kuzubova, N. V. Egorova   +6 more
doaj   +1 more source

Neurovascular Contacts in the Pathophysiology of Neuralgic Amyotrophy: An Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuralgic amyotrophy (NA) is a prevalent, monophasic, multifocal immune‐mediated neuropathy. A distinctive characteristic of the disease is the occurrence of nerve or fascicle constrictions and torsions (NA‐associated focal nerve lesions, NAFL). The pathophysiology underlying this phenomenon remains to be fully elucidated.
Johannes Fabian Holle, Andreas Leha, Volker Limmroth, Wolfram Windisch, Maximilian Zimmermann   +4 more
wiley   +1 more source

Myocardial tissue Doppler velocities in fetuses with hypoplastic left heart syndrome

Annals of Pediatric Cardiology, 2011
Background : Tissue Doppler Imaging (TDI) is a sensitive index of myocardial function. Its role in the fetus has not been extensively evaluated. Objective: To compare myocardial tissue Doppler velocities in fetuses with hypoplastic left heart syndrome ...
Himesh V Vyas, Benjamin W Eidem, Frank Cetta, Ganesh Acharya, James Huhta, David Roberson, Bettina Cuneo   +6 more
doaj   +1 more source

Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging

npj Aging and Mechanisms of Disease, 2020
Skin aging is driven by intrinsic and extrinsic factors impacting on skin functionality with progressive age. One factor of this multifaceted process is cellular senescence, as it has recently been identified to contribute to a declining tissue ...
Regina Weinmüllner, Barbara Zbiral, Adnan Becirovic, Elena Maria Stelzer, Fabian Nagelreiter, Markus Schosserer, Ingo Lämmermann, Lisa Liendl, Magdalena Lang, Lucia Terlecki-Zaniewicz, Orestis Andriotis, Michael Mildner, Bahar Golabi, Petra Waidhofer-Söllner, Karl Schedle, Gerhard Emsenhuber, Philipp J. Thurner, Erwin Tschachler, Florian Gruber, Johannes Grillari   +19 more
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Prognostic value of tissue Doppler E/e' ratio in hypertension patients with preserved left ventricular ejection fraction

Clinical and Experimental Hypertension, 2018
Objectives: This study aims to investigate the association of tissue Doppler E/e' with cardiac events in hypertension patients, independent of and incremental to clinical and left ventricular geometric patterns.
Dan Zhou, Yuqing Huang, Ming Fu, Anping Cai, Songtao Tang, Yingqing Feng   +5 more
doaj   +1 more source

Combining SPECT and Quantitative EEG Analysis for the Automated Differential Diagnosis of Disorders with Amnestic Symptoms

Frontiers in Aging Neuroscience, 2017
Single photon emission computed tomography (SPECT) and Electroencephalography (EEG) have become established tools in routine diagnostics of dementia.
Yvonne Höller, Arne C. Bathke, Andreas Uhl, Nicolas Strobl, Adelheid Lang, Jürgen Bergmann, Raffaele Nardone, Raffaele Nardone, Raffaele Nardone, Fabio Rossini, Harald Zauner, Margarita Kirschner, Amirhossein Jahanbekam, Eugen Trinka, Eugen Trinka, Wolfgang Staffen   +15 more
doaj   +1 more source