Results 41 to 50 of about 242,429 (195)

COSMOS: a platform for real-time morphology-based, label-free cell sorting using deep learning

Communications Biology, 2023
Cells are the singular building blocks of life, and a comprehensive understanding of morphology, among other properties, is crucial to the assessment of underlying heterogeneity.
Mahyar Salek, Nianzhen Li, Hou-Pu Chou, Kiran Saini, Andreja Jovic, Kevin B. Jacobs, Chassidy Johnson, Vivian Lu, Esther J. Lee, Christina Chang, Phuc Nguyen, Jeanette Mei, Krishna P. Pant, Amy Y. Wong-Thai, Quillan F. Smith, Stephanie Huang, Ryan Chow, Janifer Cruz, Jeff Walker, Bryan Chan, Thomas J. Musci, Euan A. Ashley, Maddison (Mahdokht) Masaeli   +22 more
doaj   +1 more source

OCT-Embedded Tissue Preparation v1

, 2022
This protocol describes embedding of tissue samples in optimal cutting temperature (OCT) compound (Lin & Lin, 2020). Tissue embedded in OCT can then undergo frozen sectioning on a microtome-cryostat. The advantage of OCT embedding is it requires minimal tissue processing and tissue does not need to undergo fixation prior to snap freezing.
Stephen Fisher, Marielena Grijalva, Rong Guo, Sarah A Johnston, Hieu Nguyen, John Renz, Jean G Rosario, Steven Rudich, Brian Gregory, Junhyong Kim, Kate O'Neill   +10 more
openaire   +1 more source

An optimized approach and inflation media for obtaining complimentary mass spectrometry-based omics data from human lung tissue

Frontiers in Molecular Biosciences, 2022
Human disease states are biomolecularly multifaceted and can span across phenotypic states, therefore it is important to understand diseases on all levels, across cell types, and within and across microanatomical tissue compartments.
Jessica K. Lukowski, Heather Olson, Marija Velickovic, Juan Wang, Jennifer E. Kyle, Young-Mo Kim, Sarah M. Williams, Ying Zhu, Heidi L. Huyck, Matthew D. McGraw, Cory Poole, Lisa Rogers, Ravi Misra, Theodore Alexandrov, Charles Ansong, Gloria S. Pryhuber, Geremy Clair, Joshua N. Adkins, James P. Carson, Christopher R. Anderton   +19 more
doaj   +1 more source

Graph Transformations and Game Theory: A Generative Mechanism for Network Formation [PDF]

, 2008
Many systems can be described in terms of networks with characteristic structural properties. To better understand the formation and the dynamics of complex networks one can develop generative models.
Cavaliere, Matteo, Csikasz-Nagy, Attila, Jordan, Ferenc   +2 more
core  

Deep Lesion Graphs in the Wild: Relationship Learning and Organization of Significant Radiology Image Findings in a Diverse Large-scale Lesion Database

, 2018
Radiologists in their daily work routinely find and annotate significant abnormalities on a large number of radiology images. Such abnormalities, or lesions, have collected over years and stored in hospitals' picture archiving and communication systems ...
A Esteva, A Teramoto, AAA Setio, Geert Litjens, Guohui Wei, Hayit Greenspan, HC Shin, Helen Hong, Hoo-Chang Shin, JANE BROMLEY, JH Moltz, Jinzheng Cai, Johannes Hofmanninger, Jonathan Krause, Jose Ramos, JS Silva, Ke Yan, Kenneth Clark, M Everingham, M Sevenster, Nima Tajbakhsh, Tsung-Yi Lin, Zhe Wang, Zhongyu Li   +23 more
core   +1 more source

Revolutionizing Tissue Clearing and 3-Dimensional Imaging: Transparent Embedding Solvent System for Uniform High-Resolution Imaging

BME Frontiers
Combining transparent embedding with sectioning is likely to be the future direction for tissue clearing and 3-dimensional (3D) imaging. A newly published transparent embedding system, TESOS (Transparent Embedding Solvent System), ensures consistent ...
Yating Yi, Hu Zhao
doaj   +1 more source

Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation

Nature Communications, 2018
X-ray radiation has excellent tissue penetration depth, making it a useful trigger for deep tissue cancer therapy. Here, the authors design X-ray triggered drug/gene-loaded liposomes by embedding photosensitizers and gold nanoparticles in the liposome ...
Wei Deng, Wenjie Chen, Sandhya Clement, Anna Guller, Zhenjun Zhao, Alexander Engel, Ewa M. Goldys   +6 more
doaj   +1 more source

Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury. [PDF]

, 2019
Acute kidney injury (AKI) can be fatal and is a well-defined risk factor for the development of chronic kidney disease. Group 2 innate lymphoid cells (ILC2s) are innate producers of type-2 cytokines and are critical regulators of homeostasis in ...
Cameron, Guy JM, Cautivo, Kelly M, Deshpande, Aniruddh V, Foster, Paul S, Hansbro, Philip M, Jiang, Simon H, Loering, Svenja, McKenzie, Andrew NJ, Molofsky, Ari B, Starkey, Malcolm R   +9 more
core   +4 more sources

Subcellular organization of UBE3A in human cerebral cortex. [PDF]

, 2018
BackgroundLoss of UBE3A causes Angelman syndrome, whereas excess UBE3A activity appears to increase the risk for autism. Despite this powerful association with neurodevelopmental disorders, there is still much to be learned about UBE3A, including its ...
Burette, Alain C, Chang, Edward F, Judson, Matthew C, Li, Alissa N, Philpot, Benjamin D, Seeley, William W, Weinberg, Richard J   +6 more
core   +3 more sources

Sample preparation and data collection for serial block face scanning electron microscopy of mammalian cell monolayers.

PLoS ONE
Volume electron microscopy encompasses a set of electron microscopy techniques that can be used to examine the ultrastructure of biological tissues and cells in three dimensions.
Noelle V Antao, Joseph Sall, Christopher Petzold, Damian C Ekiert, Gira Bhabha, Feng-Xia Liang   +5 more
doaj   +1 more source