Knowledge Graphs for Indication Expansion: An Explainable Target-Disease Prediction Method
Frontiers in Genetics, 2022 Indication expansion aims to find new indications for existing targets in order to accelerate the process of launching a new drug for a disease on the market. The rapid increase in data types and data sources for computational drug discovery has fostered
Ozge Gurbuz +6 more
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A single-nucleus RNA-sequencing pipeline to decipher the molecular anatomy and pathophysiology of human kidneys [PDF]
, 2019 Defining cellular and molecular identities within the kidney is necessary to understand its organization and function in health and disease. Here we demonstrate a reproducible method with minimal artifacts for single-nucleus Droplet-based RNA sequencing (
Chen, Song +12 more
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Monoclonal antibodies against human astrocytomas and their reactivity pattern [PDF]
, 1987 The establishment of hybridomas after fusion of X63-Ag8.653 mouse myeloma cells and splenocytes from mice hyperimmunized against human astrocytomas is presented. The animals were primed with 5 × 106 chemically modified uncultured or cultured glioma cells.
B. Martin +36 more
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IET Image Processing, 2021 In most of the digital steganography methods provided for natural digital images, the embedding of the confidential message is based on the minimisation of the defined distortion functions. It is often done based on choosing the most optimal criterion of
Hamidreza Damghani +2 more
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Predicting Spatio-Temporal Time Series Using Dimension Reduced Local States
, 2019 We present a method for both cross estimation and iterated time series prediction of spatio temporal dynamics based on reconstructed local states, PCA dimension reduction, and local modelling using nearest neighbour methods.
Datseris, George +2 more
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Experimental Control and Characterization of Autophagy in Drosophila [PDF]
, 2008 Insects such as the fruit fly Drosophila melanogaster, which fundamentally reorganize their body plan during metamorphosis, make extensive use of autophagy for their normal development and physiology.
A.D. Velentzas +18 more
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Improvised double-embedding technique of minute biopsies: A mega boon to histopathology laboratory
Indian Journal of Pathology and Microbiology, 2015 Introduction: Optimal orientation of minute mucosal biopsies is essential for a definite diagnosis in gastrointestinal pathology or to visualize neural plexuses in Hirschsprung disease.
Lokendra Yadav, Sarega Thomas, Usha Kini
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Pharmaceuticals, 2022 Fixation of samples is broadly used prior to the histological evaluation of tissue samples. Though recent reports demonstrated the ability to use fixed tissues for mass spectrometry imaging (MSI) based proteomics, glycomics and tumor classification ...
Andreas Dannhorn +7 more
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Identifying Harm Events in Clinical Care through Medical Narratives
, 2017 Preventable medical errors are estimated to be among the leading causes of injury and death in the United States. To prevent such errors, healthcare systems have implemented patient safety and incident reporting systems.
Cohan, Arman +3 more
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Reporting guidelines, review of methodological standards, and challenges toward harmonization in bone marrow adiposity research. Report of the Methodologies Working Group of the International Bone Marrow Adiposity Society [PDF]
, 2020 The interest in bone marrow adiposity (BMA) has increased over the last decade due to its association with, and potential role, in a range of diseases (osteoporosis, diabetes, anorexia, cancer) as well as treatments (corticosteroid, radiation ...
et al, +2 more
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