Results 51 to 60 of about 242,093 (272)

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Graph Transformations and Game Theory: A Generative Mechanism for Network Formation [PDF]

, 2008
Many systems can be described in terms of networks with characteristic structural properties. To better understand the formation and the dynamics of complex networks one can develop generative models.
Cavaliere, Matteo, Csikasz-Nagy, Attila, Jordan, Ferenc   +2 more
core  

Predicting survival from colorectal cancer histology slides using deep learning: A retrospective multicenter study [PDF]

, 2019
BACKGROUND: For virtually every patient with colorectal cancer (CRC), hematoxylin-eosin (HE)-stained tissue slides are available. These images contain quantitative information, which is not routinely used to objectively extract prognostic biomarkers.
Brenner, H., Chang-Claude, J., Charoentong, P., Ferber, D., Gaiser, T., Halama, N., Herpel, E., Hoffmeister, M., Jansen, L., Jäger, D., Kather, J. N., Krisam, J., Luedde, T., Marx, A., Reyes-Aldasoro, C. C., Valous, N. A., Weis, C. A., Zörnig, I.   +17 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Revolutionizing Tissue Clearing and 3-Dimensional Imaging: Transparent Embedding Solvent System for Uniform High-Resolution Imaging

BME Frontiers
Combining transparent embedding with sectioning is likely to be the future direction for tissue clearing and 3-dimensional (3D) imaging. A newly published transparent embedding system, TESOS (Transparent Embedding Solvent System), ensures consistent ...
Yating Yi, Hu Zhao
doaj   +1 more source

Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation

Nature Communications, 2018
X-ray radiation has excellent tissue penetration depth, making it a useful trigger for deep tissue cancer therapy. Here, the authors design X-ray triggered drug/gene-loaded liposomes by embedding photosensitizers and gold nanoparticles in the liposome ...
Wei Deng, Wenjie Chen, Sandhya Clement, Anna Guller, Zhenjun Zhao, Alexander Engel, Ewa M. Goldys   +6 more
doaj   +1 more source

Predicting Spatio-Temporal Time Series Using Dimension Reduced Local States

, 2019
We present a method for both cross estimation and iterated time series prediction of spatio temporal dynamics based on reconstructed local states, PCA dimension reduction, and local modelling using nearest neighbour methods.
Datseris, George, Isensee, Jonas, Parlitz, Ulrich   +2 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Medical JPEG image steganography method according to the distortion reduction criterion based on an imperialist competitive algorithm

IET Image Processing, 2021
In most of the digital steganography methods provided for natural digital images, the embedding of the confidential message is based on the minimisation of the defined distortion functions. It is often done based on choosing the most optimal criterion of
Hamidreza Damghani, Farshid Babapour Mofrad, Leila Damghani   +2 more
doaj   +1 more source

Knowledge Graphs for Indication Expansion: An Explainable Target-Disease Prediction Method

Frontiers in Genetics, 2022
Indication expansion aims to find new indications for existing targets in order to accelerate the process of launching a new drug for a disease on the market. The rapid increase in data types and data sources for computational drug discovery has fostered
Ozge Gurbuz, Gregorio Alanis-Lobato, Sergio Picart-Armada, Miao Sun, Christian Haslinger, Nathan Lawless, Francesc Fernandez-Albert   +6 more
doaj   +1 more source