Results 61 to 70 of about 242,093 (272)

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Sample preparation and data collection for serial block face scanning electron microscopy of mammalian cell monolayers.

PLoS ONE
Volume electron microscopy encompasses a set of electron microscopy techniques that can be used to examine the ultrastructure of biological tissues and cells in three dimensions.
Noelle V Antao, Joseph Sall, Christopher Petzold, Damian C Ekiert, Gira Bhabha, Feng-Xia Liang   +5 more
doaj   +1 more source

Subcellular organization of UBE3A in human cerebral cortex. [PDF]

, 2018
BackgroundLoss of UBE3A causes Angelman syndrome, whereas excess UBE3A activity appears to increase the risk for autism. Despite this powerful association with neurodevelopmental disorders, there is still much to be learned about UBE3A, including its ...
Burette, Alain C, Chang, Edward F, Judson, Matthew C, Li, Alissa N, Philpot, Benjamin D, Seeley, William W, Weinberg, Richard J   +6 more
core   +3 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Evaluation of Formalin-Fixed and FFPE Tissues for Spatially Resolved Metabolomics and Drug Distribution Studies

Pharmaceuticals, 2022
Fixation of samples is broadly used prior to the histological evaluation of tissue samples. Though recent reports demonstrated the ability to use fixed tissues for mass spectrometry imaging (MSI) based proteomics, glycomics and tumor classification ...
Andreas Dannhorn, John G. Swales, Gregory Hamm, Nicole Strittmatter, Hiromi Kudo, Gareth Maglennon, Richard J. A. Goodwin, Zoltan Takats   +7 more
doaj   +1 more source

Identifying Harm Events in Clinical Care through Medical Narratives

, 2017
Preventable medical errors are estimated to be among the leading causes of injury and death in the United States. To prevent such errors, healthcare systems have implemented patient safety and incident reporting systems.
Cohan, Arman, Fong, Allan, Goharian, Nazli, Ratwani, Raj   +3 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Improvised double-embedding technique of minute biopsies: A mega boon to histopathology laboratory

Indian Journal of Pathology and Microbiology, 2015
Introduction: Optimal orientation of minute mucosal biopsies is essential for a definite diagnosis in gastrointestinal pathology or to visualize neural plexuses in Hirschsprung disease.
Lokendra Yadav, Sarega Thomas, Usha Kini
doaj   +1 more source

Deep Lesion Graphs in the Wild: Relationship Learning and Organization of Significant Radiology Image Findings in a Diverse Large-scale Lesion Database

, 2018
Radiologists in their daily work routinely find and annotate significant abnormalities on a large number of radiology images. Such abnormalities, or lesions, have collected over years and stored in hospitals' picture archiving and communication systems ...
A Esteva, A Teramoto, AAA Setio, Geert Litjens, Guohui Wei, Hayit Greenspan, HC Shin, Helen Hong, Hoo-Chang Shin, JANE BROMLEY, JH Moltz, Jinzheng Cai, Johannes Hofmanninger, Jonathan Krause, Jose Ramos, JS Silva, Ke Yan, Kenneth Clark, M Everingham, M Sevenster, Nima Tajbakhsh, Tsung-Yi Lin, Zhe Wang, Zhongyu Li   +23 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source