Results 41 to 50 of about 90,992 (266)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Synthesis and characterization of ultra-soft alginate hydrogel mimicking lung tissue

International Journal of Smart and Nano Materials
Alginate hydrogels possess properties analogous to those of the extracellular matrix (ECM). Thus, their mechanical behavior approximates soft tissue, which makes them desirable for the production of tissue-equivalent soft deformable structures.
Xiangpeng Li, Jihua Gou, Chiranjit Maiti, Olusegun J. Ilegbusi   +3 more
doaj   +1 more source

Accuracy of cone beam computed tomography in measuring thicknesses of hard-tissue-mimicking material adjacent to different implant thread surfaces

Journal of Dental Sciences, 2019
Background/purpose: To evaluate the measurement accuracy of hard-tissue thicknesses adjacent to dental implants with different thread designs on images obtained from cone beam computed tomography (CBCT) using an in vitro model.
Ching-Yu Yen, Po-Jan Kuo, Chi-Yu Lin, Nancy Nie-Shiuh Chang, Hsiang-Yin Hsiao, Yu-Tang Chin, Chi-Chun Tsai, Sheng-Yang Lee   +7 more
doaj   +1 more source

Applications of Engineering Techniques in Microvasculature Design

Frontiers in Cardiovascular Medicine, 2021
Achieving successful microcirculation in tissue engineered constructs in vitro and in vivo remains a challenge. Engineered tissue must be vascularized in vitro for successful inosculation post-implantation to allow instantaneous perfusion.
Aleen Al Halawani, Aleen Al Halawani, Ziyu Wang, Ziyu Wang, Linyang Liu, Linyang Liu, Miao Zhang, Miao Zhang, Anthony S. Weiss, Anthony S. Weiss, Anthony S. Weiss   +10 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Development of a measurement setup to determine the frictional properties of tissuemimicking materials for vascular models

Current Directions in Biomedical Engineering
In this study, a measurement setup was developed to determine the frictional properties between tissue-mimicking and implant materials. Nitinol and Polytetrafluoroethylene (PTFE) were selected as implant materials, while Polyvinyl alcohol (PVA) hydrogel ...
Karcher Alisa, Schäfer Jenny, Cattaneo Giorgio, Sanchez Daniela   +3 more
doaj   +1 more source

Development and investigation of skin melanoma phantoms for ultrasonic examination

Acta Medica Lituanica, 2013
Background. The purpose of this study was to develop skin mimicking phantoms with melanoma-like insertion with acoustic properties similar to the human skin.
Kristina Andrėkutė, Ilona Subotinaitė, Skaidra Valiukevičienė, Renaldas Raišutis   +3 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Computed Tomography Attenuation of Three-Dimensional (3D) Printing Materials—Depository to Aid in Constructing 3D-Printed Phantoms

Micromachines, 2023
Three-dimensionally printed phantoms are increasingly used in medical imaging and research due to their cost-effectiveness and customizability, offering valuable alternatives to commercial phantoms.
Yuktesh Kalidindi, Aravinda Krishna Ganapathy, Yash Nayak, Anusha Elumalai, David Z. Chen, Grace Bishop, Adrian Sanchez, Brian Albers, Anup S. Shetty, David H. Ballard   +9 more
doaj   +1 more source