Relationship of cognitive decline with glucocerebrosidase activity and amyloid‐beta 42 in DLB and PD
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective Dementia with Lewy bodies (DLB) and Parkinson's disease (PD) share clinical, pathological, and genetic risk factors, including GBA1 and APOEε4 mutations. Biomarkers associated with the pathways of these mutations, such as glucocerebrosidase enzyme (GCase) activity and amyloid‐beta 42 (Aβ42) levels, may hold potential as predictive ...
Maria Camila Gonzalez +15 more
wiley +1 more source
A Simplified Positional Cell Type Visualization using Spatially Aggregated Clusters [PDF]
arXivWe introduce a novel method for overlaying cell type proportion data onto tissue images. This approach preserves spatial context while avoiding visual clutter or excessively obscuring the underlying slide. Our proposed technique involves clustering the data and aggregating neighboring points of the same cluster into polygons.
arxiv
Electrophysiological Evaluation for Conditions of Preservation of Isolated Human Colon Tissues.
, 2001 Mikio Tomita +7 more
openalex +2 more sources
Annals of Clinical and Translational Neurology, Volume 12, Issue 3, Page 523-537, March 2025.Abstract Objective To characterize structural integrity of the lumbosacral enlargement and conus medullaris within one month after spinal cord injury (SCI). Methods Lumbosacral cord MRI data were acquired in patients with sudden onset (<7 days) SCI at the cervical or thoracic level approximately one month after injury and in healthy controls.
Silvan Büeler +15 more
wiley +1 more source
Two turtles with soft tissue preservation from the platy limestones of Germany provide evidence for marine flipper adaptations in Late Jurassic thalassochelydians. [PDF]
PLoS One, 2021 Joyce WG, Mäuser M, Evers SW.
europepmc +1 more source
Bioactive MaterialsThe chronic shortage of organs and tissues for transplantation represents a dramatic burden on healthcare systems worldwide. Tissue engineering offers a potential solution to address these shortages, but several challenges remain, with prevascularization
Sara Freitas-Ribeiro +10 more
doaj
A Pilot Study of Anatomic Double-Bundle Anterior Cruciate Ligament Reconstruction With Ligament Remnant Tissue Preservation [PDF]
, 2011 Kazunori Yasuda +5 more
openalex +1 more source
An MRI assessment of mechanisms underlying lesion growth and shrinkage in multiple sclerosis
Annals of Clinical and Translational Neurology, Volume 12, Issue 4, Page 686-700, April 2025.By applying the tensor model, we analysed lesion orientation and the directionality of lesion expansion/contraction in multiple sclerosis. Each lesion is summarized as an ellipsoid, and the tensor model is applied to calculate lesion anisotropy. From the top to the bottom white matter atlas, surface‐in gradient segmentation and venous atlas used in the
Ermelinda De Meo +9 more
wiley +1 more source
Annals of Clinical and Translational Neurology, Volume 12, Issue 3, Page 615-630, March 2025.This study aimed to assess gray matter (GM) atrophy, the contribution of white matter (WM) lesions, and consequent structural disconnectivity in minority patients with multiple sclerosis (PwMS). Minority PwMS were found to have greater lesion burden and GM atrophy. Differences in GM atrophy were partially mediated by WM pathology. Abstract Objective To
Ahmed Bayoumi +8 more
wiley +1 more source
Evaluation of different decalcifying agents on histochemical and immunohistochemical staining properties of canine osseous tissue [PDF]
Medical Laboratory JournalBackground: The purpose of tissue processing is to strengthen the tissue and place it in a suitable environment for slicing without causing damage.
Reyhaneh Shafieian +2 more
doaj