Results 201 to 210 of about 8,112,821 (345)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Brain-Resident MAIT Cells Infiltrate GL261 Tumors, and Activated MAIT Cell Signatures Are Associated With Improved Outcomes in Glioma. [PDF]

Neurol Neuroimmunol Neuroinflamm
Eddy EM, Khan MAAK, Patton T, Moi D, Wang H, Le JP, Souter MNT, Nelson AG, Dewar PM, Li S, McCluskey J, Mazzieri R, Dolcetti R, Chen Z, Barrow AD, Corbett AJ.   +15 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Sarcopenia as an independent prognostic marker in liposarcoma: A longitudinal analysis of body composition and survival. [PDF]

PLoS One
Kylies J, Priemel M, Dupree A, Frosch KH, Ballhause TM.   +4 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Correction:  Survival following Cold Storage: Possible Implications for Tissue Banking.

PLoS ONE, 2014
doaj   +1 more source

Significance of the geriatric nutritional risk index and body composition as prognostic indicators in gastric cancer patients. [PDF]

Front Oncol
Wu W, Yang W, Liu J, Wang Y, Wang Z, Zhang X.   +5 more
europepmc   +1 more source

Increased Ischemic Tissue Survival through Targeting Thrombospondin‐1

, 2007
J. Isenberg, Martin J. Romeo, M. Abu-Asab, M. Tsokas, W. A. Frazier, David Michael Roberts   +5 more
semanticscholar   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

PILRA serves as a diagnostic and prognostic biomarker and modulates the tumor immune microenvironment and immunotherapy response in breast cancer. [PDF]

Front Immunol
Shi B, Yang Y, Xing L, Chen J.
europepmc   +1 more source