Results 161 to 170 of about 35,089 (268)

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

A multimodal whole-slide foundation model for pathology. [PDF]

Nat Med
Ding T, Wagner SJ, Song AH, Chen RJ, Lu MY, Zhang A, Vaidya AJ, Jaume G, Shaban M, Kim A, Williamson DFK, Robertson H, Chen B, Almagro-Pérez C, Doucet P, Sahai S, Chen C, Chen CS, Komura D, Kawabe A, Ochi M, Sato S, Yokose T, Miyagi Y, Ishikawa S, Gerber G, Peng T, Le LP, Mahmood F.   +28 more
europepmc   +1 more source

Unlocking Strength‐Toughness Dilemma in High‐Entropy Borides by Intragranular Microstructural Reconstruction

Advanced Science, EarlyView.
An extreme non‐equilibrium process combining heavy direct current sintering and TiSi2 addition is used to construct intragranular energy dissipation units within high‐entropy boride ceramics to overcome the strength‐toughness trade‐off. The resulting ceramic demonstrates attractive mechanical properties with a flexural strength of 887 MPa and a ...
Yingjun Liu, Yuhan Yao, Yufei Zu, Zhaofu Zhang, Yang Zhang, Hongfeng Dong, Nan Zhang, Wuhao Cao, Lehao Liu, Yuan Hu, Ruiheng An, Wenhu Li, Luyi Zhu, Taotao Ai   +13 more
wiley   +1 more source

The Carillon device in the treatment of patients with functional mitral regurgitation. [PDF]

Future Cardiol
Kałmucki P, Owsik K, Baszko A, Siminiak T.   +3 more
europepmc   +1 more source

Unconventional Room‐Temperature Antisymmetric Magnetoresistance in van der Waals Fe3GaTe2/Pt Heterostructures

Advanced Science, EarlyView.
We investigated a special electrical phenomenon, known as antisymmetric magnetoresistance with four distinct resistance states, in 2D Fe3GaTe2/Pt devices at room temperature. By designing devices with two separated magnetic nanoflakes, we confirmed that the effect originates from spin–momentum locking rather than magnetic domain walls or interface ...
Yunwen Zhu, Xiaolin Luo, Fan Gong, Jinnan Liu, Zhuang Liu, Jianlei Shen, Jinjian Guo, Baijie Zhu, Wei Zhang, Zhiyong Quan, Xiaohong Xu   +10 more
wiley   +1 more source

Pediatric hypertension screening: a disparity between guidelines and practice. [PDF]

Ann Med Surg (Lond)
Ullah Z, Qureshi MA, Rashid SB, Abedeen ZU, Ur Rehman A.   +4 more
europepmc   +1 more source

Conformational Snapshots of CydDC in a Native Lipid Bilayer Coupling Heme Transport to Antibiotic Resistance

Advanced Science, EarlyView.
Phylogenetic and biochemical analyses of the heme transporter CydDC reveal its functional conservation throughout bacterial evolution and demonstrate its unique asymmetric allosteric mechanism. Furthermore, impairment of CydDC function directly affects bacterial antibiotic resistance and likely compromises antibiotic efficacy through drug efflux.
Lili Yang, Changbin Zhang, Mengyuan Lyu, Yongbo Luo, Jierou Zhang, Yujiao Chen, Lintao Luo, Wen Qiao, Xiangyangpeng Li, Yu Zhou, Zhongling Wei, Yuling Xiao, Qian Niu, Juan Zhou, Guanglin He, Binwu Ying, Zhaoming Su, Hao Chen, Xiaodi Tang, Haohao Dong   +19 more
wiley   +1 more source

Pan-Cancer Prediction of Genomic Alterations from H&E Whole-Slide Images in a Real-World Clinical Cohort. [PDF]

Genes (Basel)
Ma D, Nishikubo H, Sano T, Yashiro M.
europepmc   +1 more source

Magnetotransport Signatures of Spin–Orbit Coupling in High‐Temperature Cuprate Superconductors

Advanced Science, EarlyView.
Large angle‐dependent magnetoresistance and planar Hall effects emerge at the superconducting transition of YBa2Cu3O7−x$\mathrm{YBa_2Cu_3O_{7-x}}$ thin films. These anomalous transport signatures, absent in the normal state, point to spin‐polarized quasiparticle dynamics enabled by an unexpected spin–orbit coupling landscape in cuprate superconductors,
Aleix Barrera, Huidong Li, Thomas Gunkel, Jordi Alcalá, Silvia Damerio, Can Onur Avci, Anna Palau   +6 more
wiley   +1 more source

"Comment on Nicorandil in preventing contrast-induced nephropathy in patients undergoing cardiac catheterization procedures a systematic review and meta-analysis": a systematic review and meta-analysis". [PDF]

Ann Med Surg (Lond)
Aizaz MAR, Aziz U, Jaber Amin MH.
europepmc   +1 more source