Results 211 to 220 of about 73,963 (298)

DeepLNM: A Multimodal Model for Predicting Lymph Node Metastasis in Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
Traditional diagnosis may miss positive LNM cases, and pathologists face a workload; therefore, we develop DeepLNM, a multimodal model that predicts lymph node metastasis in colorectal cancer from H&E WSIs, CT images, and text. DeepLNM is robust across internal, external, and prospective cohorts and, in a user study, improves diagnostic accuracy while ...
Zhengyu Zhang   +24 more
wiley   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao   +8 more
wiley   +1 more source

A Scalable Droplet Microfluidic Platform That Overcomes Large‐Cell Constraints for Long‐Term Plant Cell Culture and Embryogenesis Analysis

open access: yesAdvanced Science, EarlyView.
This work presents a large‐cell‐compatible droplet microfluidic platform that overcomes long‐standing barriers in plant cell culture by enabling high‐fidelity encapsulation, novel multilayer 3D droplet incubation for scalable long‐term culture, and support for the full developmental progression of large plant cells.
Arman Mirmiran   +10 more
wiley   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

open access: yesAdvanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng   +7 more
wiley   +1 more source

Structure and Dynamics in the Magnetotails of Unmagnetized and Weakly Magnetized Bodies. [PDF]

open access: yesSpace Sci Rev
Stergiopoulou K   +13 more
europepmc   +1 more source

Spin Splitting Coupled Visible‐Light Driven Injection Photocurrent in Bilayer Altermagnets

open access: yesAdvanced Science, EarlyView.
Interlayer engineering in bilayer altermagnets continuously tunes visible‐light injection photocurrents, accompanied by controllable altermagnetic spin splitting. Enhanced interlayer hybridization reconstructs the band and quantum geometries, leading to opposite evolution of the normal and magnetic injection currents and establishing a direct ...
Huanhuan Yang   +3 more
wiley   +1 more source

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