Results 281 to 290 of about 221,480 (386)

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source

A network meta-analysis of the safety of systemic treatments in patients with metastatic hormone-sensitive prostate cancer. [PDF]

Front Oncol
Di Maio M, Gonzalez-Billalabeitia E, Marandino L, Maroto P, Timsit MO, Luccarini I, Robinson P, Van Sanden S, Hadaschik BA.   +8 more
europepmc   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Fitusiran (Qfitlia) as a first-in-class RNA interference therapeutic: targeting antithrombin for prophylactic hemostasis in hemophilia. [PDF]

Ann Med Surg (Lond)
Haider E, Preety F, Sheikh M, Akhtar R, Iloke CV, Oduoye MO.   +5 more
europepmc   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Cryptococcus neoformans responds to presence of mycobacterium by diversifying its morphologies and remodelling its capsular material

Ross O, Mukaremera L, Dambuza IM.
europepmc   +1 more source

Hydrogen cyanide and hydrocarbons mix on Titan. [PDF]

Proc Natl Acad Sci U S A
Izquierdo-Ruiz F, Cable ML, Hodyss R, Vu TH, Sandström H, Lobato A, Rahm M.   +6 more
europepmc   +1 more source

Bounds on the thermodynamical properties of the fluid envelope of a planet based upon its radiative budget at the top of the atmosphere: theory and results for Earth, Mars, Titan, and Venus [PDF]

, 2010
Valerio Lucarini, Klaus Fraedrich
openalex  

Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways

Advanced Science, EarlyView.
In this article, Shuai and colleagues found that depletion of Sorcs3 could activate totipotency in mESCs, promising bidirectional differentiation potential to embryonic and extraembryonic lineages. The underlying mechanism might be activation of Tfap2c and repression of TGF‐β, PI3K‐AKT, and lysosome pathways.
Wenhao Zhang, Xinyu Mao, Yu He, Qingshen Jia, Yiding Zhao, Xiaomeng Dai, Xiaoyan Li, Shengyi Sun, Xiaoyan Sheng, Dan Ding, Yuan Shi, Qian Gao, Ling Shuai   +12 more
wiley   +1 more source

Effects of Nitrogen and Phosphorus on Estuarine Phytoplankton Communities in Aquatic Microcosms. [PDF]

Toxics
Ling J, Wei C, Yang D, Zeng J, Cheng F, Zheng X, Yang Z.   +6 more
europepmc   +1 more source