Results 221 to 230 of about 661,992 (346)

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Quantifying the Acidification-Induced Shift of the Dimerization Equilibrium of PsbS. [PDF]

J Phys Chem Lett
Vitória S, Liguori N, Croce R, Baptista AM.   +3 more
europepmc   +1 more source

Spatially Selective Solvation Chemistry by Local Charge Enrichment for Stable Potassium‐Metal Anodes

Advanced Science, EarlyView.
A MoC/NC functional intermediate medium preferentially interacts with KFSI to reconstruct the interfacial solvation structure and form a KF‐rich inorganic SEI. The synergistic integration of the electronically insulating SEI and MoC/NC suppresses electron tunneling, enables fast and balanced K+/electron transport, and promotes uniform K deposition for ...
Lu‐Kang Zhao, Xi‐Ran Zhao, Zhimin Ding, Yu‐Hua Bian, Xuan‐Chen Wang, Dongdong Zhao, Yizhuo Zhao, Xuan‐Wen Gao, Zhaomeng Liu, Wen‐Bin Luo   +9 more
wiley   +1 more source

Negative cooperativity in the formation of two H-bonds with an oxygen H-bond acceptor. [PDF]

Chem Sci
Misuraca MC, Hunter CA.
europepmc   +1 more source

Dual Physiological Barriers Bypassed by a Silk‐Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease

Advanced Science, EarlyView.
A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu, Tiandong Li, Jian He, Yujian Jiang, Yeyuan Wang, Jingchen Sun   +5 more
wiley   +1 more source

Anesthetics in status epilepticus: does one size fits it all?-A scoping review on titration goals, timing, and patient selection. [PDF]

Front Neurol
Fisch U, De Stefano P, Baumann SM, Rüegg S, Sutter R.   +4 more
europepmc   +1 more source

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

THE TITRATION CURVE OF GLUTATHIONE

, 1929
N. Pirie, Kathleen Godwin Pinhey
semanticscholar   +1 more source

Cucurbit[8]Uril Achieved Single‐Molecule Chiral Transfer to Supramolecular Circularly Polarized Luminescence

Advanced Science, EarlyView.
A single‐molecule cascade supramolecular system comprising L/D‐FPy, CB[8], and SC4AD serves as an efficient light‐harvesting platform. It facilitates cascade energy transfer and chiral transfer to acceptor dyes. Co‐assembly with a PVA matrix produces a multicolor solid film that exhibits enhanced luminescence dissymmetry factors (glum), enabling ...
Yongxue Li, Jie Wu, Weiheng Zhang, Hengzhi Zhang, Wei‐Lei Zhou, Yu Liu   +5 more
wiley   +1 more source