Results 131 to 140 of about 1,889,593 (284)
Tight junction proteins: Gatekeepers turned facilitators in the pathogenesis of gastric adenocarcinoma. [PDF]
World J Gastrointest OncolSelvam S, Vairappan B.
europepmc +1 more source
Advanced Science, EarlyView.The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen +15 more
wiley +1 more source
An insulin receptor activity surge in follicle cells drives vitellogenesis by upregulating CrebA. [PDF]
EMBO RepWang X +6 more
europepmc +1 more source
Advanced Science, EarlyView.The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo +8 more
wiley +1 more source
Junctions, Transporters, and Interactions of Endothelial Cells: Regulation by Ethanol. [PDF]
Int J Mol SciMandyam CD +5 more
europepmc +1 more source
Advanced Science, EarlyView.In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen +15 more
wiley +1 more source
Activated notch signaling pathway protects the intestinal barrier in DSS-induced colitis by regulating tight junctions. [PDF]
Eur J Med ResLi T +5 more
europepmc +1 more source