Results 171 to 180 of about 255,384 (338)

The E3 Ligase RNF115 Aggravates Pathological Cardiac Hypertrophy via Ubiquitin‐Mediated Degradation of SPTBN1

Advanced Science, EarlyView.
In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu, Shiqing Chen, Ji Chen, Liuliu Ruan, Bowen Li, Weijian Chu, Shichen Huang, Dian Yu, Jing Tian, Yuhan Zhao, Yi Han, Xin Tang, Yong Ji   +12 more
wiley   +1 more source

Nanoscopic analysis of tight junction organization in in vitro blood-brain barrier models. [PDF]

Fluids Barriers CNS
Waldow A, Brachner A, Perriere N, Neuhaus W, Piontek J.   +4 more
europepmc   +1 more source

Integrated data analysis at TJ-II: the density profile.

Review of Scientific Instruments, 2011
B. V. van Milligen, T. Estrada, E. Ascasíbar, D. Tafalla, D. Lopez-Bruna, A. López Fraguas, J. Jimenez, I. García-Cortés, A. Dinklage, R. Fischer   +9 more
semanticscholar   +1 more source

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source

ReFerm® a Fermented Oat Gruel Composition, Improves Colonic Barrier Function and Modulates Tricellulin Expression in Patients With Irritable Bowel Syndrome. [PDF]

Neurogastroenterol Motil
Abruzzese V, Biskou O, Winberg ME, Israelsen H, Bednarska O, Walter S, Keita ÅV.   +6 more
europepmc   +1 more source

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Superoxide dismutases maintain niche homeostasis in stem cell populations. [PDF]

Elife
Majhi O, Chhatre A, Chaudhary T, Sinha D.   +3 more
europepmc   +1 more source

The Effect of TJ-15 Plus TJ-17 on Atopic Dermatitis: A Pilot Study Based on the Principle of Pattern Identification

Journal of Alternative and Complementary Medicine, 2012
I. Choi, Sehyun Kim, Youngchul Kim, Y. Yun   +3 more
semanticscholar   +1 more source

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

Crypt-Level Tight Junction Remodeling Is Associated with Disease Course and Clinical Outcomes in Inflammatory Bowel Disease. [PDF]

Cells
Tsounis EP, Geramoutsou C, Pastras P, Aggeletopoulou I, Bosgana P, Lourida T, Diamantopoulou G, Ritsatou S, Koniaris E, Mantzaris GJ, Zolota V, Assimakopoulos SF, Bravou V, Thomopoulos K, Theocharis G, Triantos C.   +15 more
europepmc   +1 more source