Results 11 to 20 of about 255,384 (338)

Metformin ameliorates BSCB disruption by inhibiting neutrophil infiltration and MMP‐9 expression but not direct TJ proteins expression regulation

Journal of Cellular and Molecular Medicine, 2017
Blood‐spinal cord barrier (BSCB) disruption is a major process for the secondary injury of spinal cord injury (SCI) and is considered to be a therapeutic target for SCI.
Di Zhang, Qian Tang, Gang Zheng, Chenggui Wang, Yifei Zhou, Yaosen Wu, Jun-Hua Xuan, Naifeng Tian, Xiangyang Wang, Yan Wu, Huazi Xu, Xiaolei Zhang   +11 more
semanticscholar   +1 more source

Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients

BMC Cancer, 2019
Background Significant numbers of variants detected in cancer patients are often left labeled only as variants of unknown significance (VUS). In order to expand precision medicine to a wider population, we need to extend our knowledge of pathogenicity ...
Takahiko Koyama, Kahn Rhrissorrakrai, Laxmi Parida   +2 more
doaj   +1 more source

DIA DA MEMÓRIA DO PODER JUDICIÁRIO: 10 DE MAIO

LexCult, 2020
The main goal of this paper is to analyse the importance of the Judiciary Memorial Day instituted by the National Council of Justice. The related proposal was submitted to prior consultation before serving professionals in the field of memory
Carlos Alexandre Böttcher
doaj   +1 more source

TJ-35 suppresses autophagosome formation under starvation condition.

, 2020
A. GFP-Atg5 expressing HeLa was treated with or without TJ-35 for 4 h, and then shifted to DMEM or EBSS with or without TJ-35 for 2 h. The graph shows GFP-positive puncta per cell.
Yo-hei Yamamoto (8538018), Tamotsu Yoshimori (127877), Takeshi Noda (21623), Chao-Yuan Tsai (8538021), Sumiko Ikari (8538012), Shiou-Ling Lu (4230082), Yasuhiro Araki (25549), Yumi Nishiyama (2315947), Kenta Imai (1479865), Feike Hao (8538015), Takanobu Otomo (8538024), Nobukazu Shitan (636610)   +11 more
core   +1 more source

A Novel Role of PP2A Methylation in the Regulation of Tight Junction Assembly and Integrity

Frontiers in Cell and Developmental Biology, 2022
Tight junctions (TJs) are multiprotein complexes essential for cell polarity and the barrier function of epithelia. The major signaling molecule, protein serine/threonine phosphatase 2A (PP2A), interacts with the TJ and modulates the phosphorylation ...
Diana Schuhmacher, Jean-Marie Sontag, Estelle Sontag   +2 more
doaj   +1 more source

Randomized phase II study of TJ-54 (Yokukansan) for postoperative delirium in gastrointestinal and lung malignancy patients

Molecular and clinical oncology, 2017
The present study evaluated the efficacy and safety of TJ-54 (Yokukansan; a traditional Japanese medicine) for the prevention and/or treatment of postoperative delirium in a randomized phase II trial of patients receiving surgery for gastrointestinal and
N. Sugano, T. Aoyama, Tsutomu Sato, M. Kamiya, Shinya U. Amano, N. Yamamoto, T. Nagashima, Y. Ishikawa, K. Masudo, M. Taguri, T. Yamanaka, Yuji Yamamoto, H. Matsukawa, Ryuji Shiraisi, T. Oshima, N. Yukawa, Y. Rino, M. Masuda   +17 more
semanticscholar   +1 more source

TJ-35 suppresses autophagy under starvation condition.

, 2020
A. Tf-LC3–expressing HeLa cells were treated with or without TJ35 for 4 h, shifted to DMEM or EBSS with or without TJ-35 for 2 h, and observed on SP-8. The graph above shows GFP-positive puncta per cell.
Yo-hei Yamamoto (8538018), Tamotsu Yoshimori (127877), Takeshi Noda (21623), Chao-Yuan Tsai (8538021), Sumiko Ikari (8538012), Shiou-Ling Lu (4230082), Yasuhiro Araki (25549), Yumi Nishiyama (2315947), Kenta Imai (1479865), Feike Hao (8538015), Takanobu Otomo (8538024), Nobukazu Shitan (636610)   +11 more
core   +1 more source

Inhibitory effects of Japanese herbal medicines sho-saiko-to and juzen-taiho-to on nonalcoholic steatohepatitis in mice. [PDF]

PLoS ONE, 2014
Although Japanese herbal medicines (JHMs) are widely used in Japan, only a few studies have investigated their effects on nonalcoholic steatohepatitis (NASH). In the present study, we examined the effect of 4 kinds of JHMs [sho-saiko-to (TJ-9), inchin-ko-
Yoshihisa Takahashi, Yurie Soejima, Arisa Kumagai, Masato Watanabe, Hiroshi Uozaki, Toshio Fukusato   +5 more
doaj   +1 more source

TJ-35 specifically suppresses dissociation of ULK1 and TFEB from mTORC1 under starvation conditions.

, 2020
A. ULK1-EGFP–expressing HeLa cells were treated with or without TJ-35 for 4 h, and shifted to DMEM or EBSS with or without TJ-35 for 2 h, and subjected to PLA using anti-GFP and mTOR antibodies. We counted 15 cells counted in two independent experiments.
Yo-hei Yamamoto (8538018), Tamotsu Yoshimori (127877), Takeshi Noda (21623), Chao-Yuan Tsai (8538021), Sumiko Ikari (8538012), Shiou-Ling Lu (4230082), Yasuhiro Araki (25549), Yumi Nishiyama (2315947), Kenta Imai (1479865), Feike Hao (8538015), Takanobu Otomo (8538024), Nobukazu Shitan (636610)   +11 more
core   +1 more source

Ion beam etching dependence of spin–orbit torque memory devices with switching current densities reduced by Hf interlayers

APL Materials, 2021
We report on the fabrication of nanoscale, three-terminal in-plane spin–orbit torque switching devices with low switching current densities. Critical parameters in the fabrication process, including the ion beam etching angle and time, were optimized to ...
Haowen Ren, Shih-Yu Wu, Jonathan Z. Sun, Eric E. Fullerton   +3 more
doaj   +1 more source