Results 21 to 30 of about 30,377 (206)

Liquid Crystalline Elastomers in Soft Robotics: Assessing Promise and Limitations

Advanced Robotics Research, EarlyView.
Liquid crystalline elastomers (LCEs) are programmable soft materials that undergo large, anisotropic deformation in response to external stimuli. Their molecular alignment encodes directional actuation in a monolithic structure, making them long‐standing candidates for soft robotic systems.
Justin M. Speregen, Timothy J. White
wiley   +1 more source

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

Symmetry, Hamiltonian Problems and Wavelets in Accelerator Physics

, 1999
In this paper we consider applications of methods from wavelet analysis to nonlinear dynamical problems related to accelerator physics. In our approach we take into account underlying algebraical, geometrical and topological structures of corresponding ...
Fedorova, Antonina N., Parsa, Zohreh, Zeitlin, Michael G.   +2 more
core   +1 more source

Dual Targeting of Mutant p53 and SNRPD2 via Engineered Exosomes Modulates Alternative Splicing to Suppress Ovarian Cancer

Advanced Science, EarlyView.
Mutant p53 drives oncogenic splicing to promote the progression of ovarian cancer by partnering with the spliceosome factor SNRPD2. Therefore, it is engineered iRGD‐exosomes to co‐deliver siRNAs against both targets. This approach restored tumor‐suppressive mRNA isoforms, effectively enhanced sensitivity to cisplatin, and ultimately blocked tumor ...
Wei Zhao, Qian Hao, Yu Gan, Jing Tong, Xiaodan Chen, Shuran Tan, Ruiwen Ruan, Yingdan Huang, Mingming Cao, Jun Deng, Tao Han, Getao Shi, Bo Gao, Yu Zhang, Xiang Zhou   +14 more
wiley   +1 more source

MicroRNA‐375‐3p Targets Fatty Acid Synthase and Relish to Regulate Energy Allocation During Pupal Metamorphosis and Starvation

Advanced Science, EarlyView.
During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen, Meiqi Cheng, Jianhui Wang, Jing Tang, Xiaoqiao Huang, Yusi Li, Huiling Zhou, Ling Zhang, Yi Dong, Chengjun Li, Bin Li   +10 more
wiley   +1 more source

New Tasks in Old Jobs: Drivers of Change and Implications for Job Quality [PDF]

, 2018
This overview report summarises the findings of 20 case studies looking at recent changes in the task content of five manufacturing occupations (car assemblers, meat processing workers, hand-packers, chemical products plant and machine operators and ...
Bisello, Martina, Eggert Hansen, Martin, Fernández-Macías, Enrique   +2 more
core   +1 more source

Profiling of Integrin Isoforms on Lung‐Tropic Exosomes by Spectrally and Kinetically Multiplexed Single‐Molecule Imaging

Advanced Science, EarlyView.
A spectrally and kinetically multiplexed single‐molecule imaging method is developed, which achieved simultaneous imaging of 12 exosomal proteins at an unparalleled single‐copy resolution. It is found that co‐occurrence of α6 integrin and the pairing β counterpart on single exosomes is essential for lung targeting, providing valuable information for ...
Songlin Liu, Haixin Wang, Qin Shentu, Liang Yuan, Jiangshan Tie, Li Li, Rui Ai, Bochen Ma, Lubin Qi, Yifei Jiang, Xiaohong Fang   +10 more
wiley   +1 more source

Opposing Pressures of Speed and Efficiency Guide the Evolution of Molecular Machines. [PDF]

, 2019
Many biomolecular machines need to be both fast and efficient. How has evolution optimized these machines along the tradeoff between speed and efficiency?
Dill, Ken, Wagoner, Jason
core  

Minimal universal quantum heat machine

, 2013
In traditional thermodynamics the Carnot cycle yields the ideal performance bound of heat engines and refrigerators. We propose and analyze a minimal model of a heat machine that can play a similar role in quantum regimes. The minimal model consists of a
Alicki, Robert, Gelbwaser-Klimovsky, David, Kurizki, Gershon   +2 more
core   +1 more source

Endocortical bone loss in osteoporosis: The role of bone surface availability [PDF]

, 2012
Age-related bone loss and postmenopausal osteoporosis are disorders of bone remodelling, in which less bone is reformed than resorbed. Yet, this dysregulation of bone remodelling does not occur equally in all bone regions. Loss of bone is more pronounced
Ausk, Bauchau, Beaupré, Bell, Boivin, Bonewald, Buenzli, Buenzli, Buenzli, Carter, Carter, Compston, Cooper, Currey, Feik, Feng, Grimal, Hambli, Hellmich, Hjelmstad, Huiskes, Iwamoto, Jang, Jee, Keaveny, Komarova, Landau, Lee, Lemaire, Lora, Manolagas, Manson, Martin, Martin, Martin, Mertz, Meulen, Oers, Orwoll, Parfitt, Pivonka, Pivonka, Pivonka, Pivonka, Poliachik, Rieger, Rizzoli, Robling, Rumpler, Ryser, Seeman, Skerry, Stein, Takata, Thomas, Thomas, Timoshenko, Uebelhart, Verborgt, Warner, Webster, Zebaze   +61 more
core   +3 more sources