Effects of climate model interdependency on the uncertainty quantification of extreme rainfall projections [PDF]
, 2012 Arnbjerg-Nielsen, Karsten +3 more
core +2 more sources
NIBAN2/FLII/RREB1 Axis Drives Glioma Stem Cell Malignancy via TLR3 Pathway Activation
Advanced Science, EarlyView.NIBAN2, highly expressed in glioma stem‐like cells (GSCs), assembles with FLII and transcription factor RREB1 to form a nuclear complex. This complex transcriptionally activates stemness‐associated genes (e.g., CD44, NANOG) and metabolic enzymes (e.g., LDHA), thereby sustaining both transcriptional and metabolic stemness programs.
Liang liang Shi +14 more
wiley +1 more source
Higher-order moments spillovers among energy, carbon and tourism markets: Time- and frequency-domain evidence. [PDF]
PLoS OneGao W, Yang S.
europepmc +1 more source
PD‐L1‐Binding Antigen Presenters: Redirecting Vaccine‐Induced Antibodies for Cancer Immunotherapy
Advanced Science, EarlyView.The PBAP‐gE complex anchors gE antigen to PD‐L1 on tumor cells. Vaccine‐induced anti‐gE antibodies simultaneously engage FcγRIIIa on NK cells and tumor‐bound PBAP‐gE, triggering NK cell activation and antibody‐dependent cellular cytotoxicity, thereby selectively eliminating PD‐L1–expressing tumor cells.
Huixin Gao +24 more
wiley +1 more source
Kinetics of Serum Myoglobin and Creatine Kinase Related to Exercise-Induced Muscle Damage and <i>ACTN3</i> Polymorphism in Military Paratroopers Under Intense Exercise. [PDF]
J Funct Morphol KinesiolAugusto RS +7 more
europepmc +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Risk factors for subsequent vertebral fracture after percutaneous vertebroplasty in patients with osteoporotic vertebral compression fractures in Northern China. [PDF]
Front SurgGuo Y, Zhao Y, Sun Q, Gao H, Zhang W.
europepmc +1 more source
Growth‐Like Swelling of 2D Precursors for Efficient Fabrication of Complex 3D Microstructures
Advanced Science, EarlyView.The growth‐like swelling process fills photocured polymers into the elastomeric microstructures, inducing a significant swelling deformation of microstructures that can be maintained in the absence of solvents. The growth‐like swelling process breaks through the dependence of swelling deformation on the solvents, thereby expanding the application of 3D
Xinkai Zhu +13 more
wiley +1 more source
Making room for reactivity in topochemical transformations under pressure. [PDF]
Chem SciLyu T +8 more
europepmc +1 more source
Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation
Advanced Science, EarlyView.PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang +9 more
wiley +1 more source