Results 171 to 180 of about 218,060 (295)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Telomere Length Abnormality: Investigating Approaches and Correlations with Cancer, Bone Marrow Failure and Hematological Malignancies. [PDF]

Biomedicines
Tarella C, Ferrero D, Herrera Sanchez MB, Canestrale AR, Kholia S, Silengo L, Derenzini E, Ricca I.   +7 more
europepmc   +1 more source

tl;dr - tl;dl?

, 2019
openaire   +2 more sources

Comparison of Irradiated Food with Electron Beam and Gamma-ray by PSL and TL Methods [PDF]

, 2013
Kyu-Heon Kim, Ji-Young Kwak, Jin-Ho Yoon, Young-Eun Park, Jae‐Hwang Lee, Yong-Chjun Park, Tae-Yong Jo, Hwa-Jung Lee, Sang Jae Lee, Sang‐Bae Han   +9 more
openalex   +1 more source

The Tumor‐to‐Endothelial Transfer of FTO Promotes Vascular Remodeling and Metastasis in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
Integrated omics analysis of matched primary and liver metastatic NPC tumors reveals a unique NOTCH1+ CSC subpopulation exhibiting enhanced stemness properties and tumorigenic capacity. With in vitro and in vivo assays, exosomal transfer of tumor‐derived FTO from NOTCH1+ cells to the endothelium promotes vascular permeability and metastatic potential ...
Chun Wu, Xuefei Liu, Liwen Gu, Jingru Lian, Yuting Wang, Yixin Cheng, Lianhui Duan, Guanyin Huang, Siqi Chen, Boxi Zhao, Sailan Liu, Yufan Yang, Shuqian Zheng, Zijian Lu, Wanping Guo, Jianyang Hu, Wenjing Wang, Zhixiang Zuo, Haiqiang Mai, LinQuan Tang, Songfa Zhang, Feiqiu Wen, Xin Hong, Ling Guo   +23 more
wiley   +1 more source

Grandmother Age Effects via Sperm Telomere Length and Egg Telomerase Transcripts. [PDF]

Mol Ecol
Kim SY, Chiara V, Velando A.
europepmc   +1 more source

[Tl₇]^7– Clusters in Mixed Alkali Metal Thallides Cs_7.29K_5.71Tl₁₃ and Cs_3.45K_3.55Tl₇ [PDF]

Vanessa F. Schwinghammer, Stefanie Gärtner   +1 more
openalex   +1 more source

An Indirect Radioimmunoassay for Thymus Leukemia (TL) Antigens [PDF]

, 1976
Naomi L. Esmon, John R. Little
openalex   +1 more source

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

Advanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman   +13 more
wiley   +1 more source