Results 41 to 50 of about 313,494 (287)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Evaluation of Selected Groundnut (Arachis hypogaea L.) Lines for Yield and Haulm Nutritive Quality Traits

open access: yesInternational Journal of Agronomy, 2017
Groundnut, the most important grain legume in Ghana, is largely cultivated under rainfed conditions within the Guinea savanna zone of the country. The pods and haulms are important sources of income for smallholder farmers in the region.
Richard Oteng-Frimpong   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Phytochemical analysis, enumeration, isolation, and antimicrobial activity of lemongrass and moringa leaves extracts

open access: yesJournal of Agriculture and Food Research, 2023
The study aimed at enumerating and isolating Lactobacillus from sorghum beer (Pito) which is one of the food spoilage bacteria in pito, evaluating the antibacterial potency of lemongrass (Cymbopogon citratus) and Moringa leave methanolic extract (Moringa
Patrick Owusu-Ansah   +6 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Growth performance and hematology of Djallonké rams fed haulms of four varieties of groundnut (Arachis hypogaea L.)

open access: yesAnimal Nutrition, 2017
The study was conducted to assess the chemical composition of the haulms of 4 dual-purpose groundnut (Arachis hypogaea L.) varieties and their effects on the growth and hematology of Djallonké rams.
Terry Ansah   +2 more
doaj   +1 more source

Automatic Registration of TLS-TLS and TLS-MLS Point Clouds Using a Genetic Algorithm [PDF]

open access: yesSensors, 2017
Registration of point clouds is a fundamental issue in Light Detection and Ranging (LiDAR) remote sensing because point clouds scanned from multiple scan stations or by different platforms need to be transformed to a uniform coordinate reference frame.
Li Yan 0003   +4 more
openaire   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

open access: yesFEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim   +11 more
wiley   +1 more source

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