Results 11 to 20 of about 29,232 (135)

RXCJ1111.6+4050 galaxy cluster: Observational evidence of a transitional fossil group [PDF]

Astronomy & Astrophysics, 2023
We present a detailed kinematical and dynamical study of the galaxy cluster RXCJ1111.6+4050 (RXCJ1111), at z = 0.0756 using 104 new spectroscopic redshifts of galaxies observed at the TNG 3.5m telescope and SDSS DR16 public archive.
R. Barrena, G. Chon, H. Bohringer, J. M'endez-Abreu, A. Ferragamo   +4 more
semanticscholar   +1 more source

Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes with an MT-TL1 m.3243A>G point mutation: Neuroradiological features and their implications for underlying pathogenesis

Frontiers in Neuroscience, 2023
Objective Mitochondrial encephalomyopathy with lactic acidosis and stroke−like episodes (MELAS) is one of the most common inherited mitochondrial disorders.
Helin Zheng, Xuemei Zhang, L. Tian, Bo Liu, Xiaoya He, Longlun Wang, Shuang Ding, Yi Guo, Jinhua Cai   +8 more
semanticscholar   +1 more source

Changes in histopathology and heteroplasmy rates over 8 years and effectiveness of taurine supplementation in a patient with mitochondrial nephropathy caused by MT-TL1 mutation: A case report.

Heliyon, 2023
The m.3243A > G mutation in the mitochondrially encoded tRNA leucine 1 (MT-TL1) gene is known to cause mitochondrial nephropathy. However, its long-term effects of the m.3243A > G mutation on renal histopathology or heteroplasmy rates remain unknown ...
T. Imasawa, H. Kitamura, Takehiko Kawaguchi, Y. Yatsuka, Yasushi Okazaki, K. Murayama   +5 more
semanticscholar   +1 more source

Elemental Substitution at Tl Site of Tl1−xXx(Ba, Sr)CaCu2O7 Superconductor with X = Cr, Bi, Pb, Se, and Te

Materials, 2023
The effects of elemental substitutions at the Tl site of a Tl1−xXx(Ba, Sr)CaCu2O7 superconductor with X = Cr, Bi, Pb, Se, and Te were investigated.
J. Nur-Akasyah, R. Abd-Shukor, T. V. Chong   +2 more
semanticscholar   +1 more source

120 Using Implementation Science to Develop a TL1 D&I Science Training Implementation Plan

Journal of Clinical and Translational Science, 2023
OBJECTIVES/GOALS: The training needs of clinical & translational scientists are evolving. Implementation of new curriculum content requires assessment of need, fit with current curriculum, incentives and barriers to implementation. We used implementation
A. Rodday, Alyssa B. Cabrera, Anna L. Thompson, T. Concannon, R. Sege, Elizabeth Leary   +5 more
semanticscholar   +1 more source

A MT-TL1 variant identified by whole exome sequencing in an individual with intellectual disability, epilepsy, and spastic tetraparesis

European Journal of Human Genetics, 2021
The genetic etiology of intellectual disability remains elusive in almost half of all affected individuals. Within the Solve-RD consortium, systematic re-analysis of whole exome sequencing (WES) data from unresolved cases with (syndromic) intellectual ...
E. de Boer, C. Ockeloen, L. Matalonga, R. Horvath, Enzo Isabel Daniel Anne-Sophie Yannis Christian Mridul Cohen Cuesta Danis Denommé-Pichon Duffourd Gilisse, Enzo Cohen, I. Cuesta, D. Danis, A. Denommé-Pichon, Y. Duffourd, C. Gilissen, M. Johari, S. Laurie, Shuang Li, I. Nelson, S. Peters, I. Paramonov, Sivakumar Prasanth, P. Robinson, K. Šablauskas, M. Savarese, W. Steyaert, Ana Töpf, Joeri Van der Velde, A. Vitobello, R. Rodenburg, M. Coenen, M. Janssen, Dylan Henssen, C. Gilissen, W. Steyaert, Siddharth Elisa Giorgio Andrea Jill Bruno Elke Laurence Tobi Banka Benetti Casari Ciolfi Clayton-Smith Dallapic, S. Banka, Elisa Benetti, G. Casari, A. Ciolfi, J. Clayton-Smith, B. Dallapiccola, E. de Boer, L. Faivre, T. Haack, A. Hammarsjö, M. Havlovicová, A. Hoischen, A. Hugon, A. Jackson, T. Kleefstra, A. Lindstrand, Estrella López-Martín, M. Macek, Vicenzo Nigro, A. Nordgren, M. Pettersson, M. Pinelli, S. Pizzi, M. Posada, F. Radio, A. Renieri, C. Rooryck, L. Ryba, M. Schwarz, M. Tartaglia, C. Thauvin, A. Torella, A. Verloes, Lisenka Vissers, Klea Vyshka, B. Zurek, A. Trimouille, T. Kleefstra, A. Verloes, L. Vissers   +71 more
semanticscholar   +2 more sources

Acute mountain sickness and sleep disturbances differentially influence cognition and mood during rapid ascent to 3000 and 4050 m

Physiological Reports, 2022
The impact of acute mountain sickness (AMS) and sleep disturbances on mood and cognition at two altitudes relevant to the working and tourist population is unknown. Twenty unacclimatized lowlanders were exposed to either 3000 m (n = 10; 526 mmHg) or 4050
Peter S. Figueiredo, I. Sils, J. Staab, C. Fulco, S. Muza, B. Beidleman   +5 more
semanticscholar   +1 more source

Impediments to Heart Transplantation in Adults With MELASMT-TL1:m.3243A>G Cardiomyopathy.

Journal of the American College of Cardiology, 2022
BACKGROUND The heart is commonly involved in maternally inherited mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome caused by the MT-TL1 m.3243A>G mutation of the mitochondrial DNA.
A. Di Toro, Mario Urtis, N. Narula, L. Giuliani, M. Grasso, M. Pasotti, C. Pellegrini, A. Serio, A. Pilotto, E. Antoniazzi, T. Rampino, L. Magrassi, A. Valentini, A. Cavallini, L. Scelsi, S. Ghio, M. Abelli, I. Olivotto, M. Porcu, A. Gavazzi, T. Kodama, E. Arbustini   +21 more
semanticscholar   +1 more source

Evaluation of the tRNA-Leu (UUR) gene haplotype profile observed in canine mammary gland tumours based on comparative analysis with the MT-TL1 human gene

Annals of Animal Science, 2022
The aetiology and pathogenesis of many canine tumours are likely to be similar to cancers found in humans. This study aimed to evaluate a plausible link between changes in the tRNA-Leu (UUR) gene and the carcinogenesis process in dogs with mammary gland ...
Krzysztof Kowal, Angelika Tkaczyk-Wlizło, Mariusz Pierzchała, B. Ślaska   +3 more
semanticscholar   +1 more source

Educational initiative in an NCATS TL1 training program to address the impact of systemic racism on human health, biomedical research, and the translational scientist

Journal of Clinical and Translational Science, 2022
Introduction: The goal of clinical and translational science (CTS) is to fill gaps in medical knowledge toward improving human health. However, one of our most pressing challenges does not reside within the biological map we navigate to find sustainable ...
Martha D. Gay, K. Bell, Emily Bujold, M. Geraci, Dexter L. Lee, Kathryn Sandberg, R. Speth   +6 more
semanticscholar   +1 more source