Results 61 to 70 of about 24,071 (113)

A multi-optional hybrid functions entropy as a tool for transportation means repair optimal periodicity determination

open access: yesAviation, 2018
The paper considers theoretical explanation and construction of some mathematical models of a transportation mean operational process in reference to maintenance optimal periodicity.
Andriy Goncharenko
doaj   +1 more source

Treatment with PBI-4050 in patients with Alström syndrome: study protocol for a phase 2, single-Centre, single-arm, open-label trial

open access: yesBMC Endocrine Disorders, 2018
BackgroundAlström syndrome (ALMS) is a very rare autosomal recessive monogenic disorder caused by a mutation in the ALMS1 gene and characterised by childhood onset obesity, dyslipidaemia, advanced non-alcoholic fatty liver disease, diabetes and extreme ...
S. Baig   +8 more
semanticscholar   +1 more source

Application of automated trajectory design for pilot flight assessment during route flights

open access: yesAviation, 2017
Flight accuracy in the airspace is becoming an increasingly difficult issue due to the expanding number of aircraft operating in it. In order to meet the needs of all airspace users, aircraft flows are being increased, and different aircraft systems that
Tadas Masiulionis   +4 more
doaj   +1 more source

Inspection program development for fatigue crack growth model with two random parameters/Apžiūrų programos kūrimas nuovargio plyšio augimo modeliui su dviem atsitiktiniais parametrais

open access: yesAviation, 2008
To keep the fatigue failure probability of an aircraft fleet at or below a certain level, an inspection program is appointed to discover fatigue cracks before they decrease the residual strength of some structurally significant item of the airframe lower
Yuri Paramonov, Andrey Kuznetsov
doaj   +1 more source

Dissolved oxygen control strategy for improvement of TL1-1 production in submerged fermentation by Daldinia eschscholzii

open access: yesBioresources and Bioprocessing, 2017
Background2,3-Dihydro-5-hydroxy-2-methylchromen-4-one (TL1-1) is a phenolic compound with significant anti-fungal and anti-cancer activities produced by Daldinia eschscholzii (D. eschscholzii).
Xing-chen Wei, L. Tang, Yanhua Lu
semanticscholar   +1 more source

Modeling of defects in electronic navigation devices operating in extreme conditions

open access: yesAviation, 2008
An investigation of the corrosive and mechanical destruction of microelectronic objects such as multipurpose sensors and navigating devices used in the airspace industry in extreme conditions such as variable temperature, pressure and environmental ...
Alexander Bogorosh   +6 more
doaj   +1 more source

PBI-4050 via GPR40 activation improves adenine-induced kidney injury in mice.

open access: yesClinical science, 2019
PBI-4050, a novel first-in-class orally active compound that has completed clinical phases Ib and II in subjects with CKD and metabolic syndrome respectively, exerts antifibrotic effects in several organs via a novel mechanism of action, partly through ...
J. Thibodeau   +12 more
semanticscholar   +1 more source

Can the renewed interest in ultra-long-range passenger flights be satisfied by the current generation of civil aircraft?

open access: yesAviation, 2018
A number of full service network carriers have recently stated their ambition to develop certain ultra-long-range (ULR) routes, such as Doha to Auckland, Dubai to Auckland, Dubai to Panama City, Singapore to San Francisco, Singapore to New York, all of ...
Glenn S. Baxter, Nicholas S. Bardell
doaj   +1 more source

PBI-4050 Reduces Stellate Cell Activation and Liver Fibrosis through Modulation of Intracellular ATP Levels and the Liver Kinase B1/AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway

open access: yesJournal of Pharmacology and Experimental Therapeutics, 2018
Hepatic fibrosis is a major cause of morbidity and mortality for which there is currently no effective therapy. We previously showed that 2-(3-pentylphenyl)acetic acid (PBI-4050) is a dual G protein–coupled receptor GPR40 agonist/GPR84 antagonist that ...
B. Grouix   +15 more
semanticscholar   +1 more source

Numerical simulation for random aeroelastic responses using inverse fourier transform

open access: yesAviation, 2016
This paper reports a new simulation technique for an aeroelastic system which responds to random external forces. Since the aeroelastic system including the effects of unsteady aerodynamics is ordinarily described in the frequency domain, the Inverse ...
Tetsuhiko Ueda, Kenichi Saitoh
doaj   +1 more source

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