Deletion of the Candida albicans TLO gene family using CRISPR-Cas9 mutagenesis allows characterisation of functional differences in α-, β- and γ- TLO gene function [PDF]
PLoS Genetics, 2023 The Candida albicans genome contains between ten and fifteen distinct TLO genes that all encode a Med2 subunit of Mediator. In order to investigate the biological role of Med2/Tlo in C.
Jessica Fletcher +2 more
exaly +4 more sources
Deletion of the Candida albicans TLO gene family results in alterations in membrane sterol composition and fluconazole tolerance [PDF]
PLoS ONEDevelopment of resistance and tolerance to antifungal drugs in Candida albicans can compromise treatment of infections caused by this pathogenic yeast species. The uniquely expanded C.
Jessica Fletcher +2 more
exaly +3 more sources
Expansion of the TLO gene family enhances the virulence of Candida species
PLoS ONE, 2018 The TLO genes are a family of subtelomeric ORFs in the fungal pathogens Candida albicans and C. dubliniensis encoding a subunit of the Mediator complex homologous to Med2. The more virulent pathogen C.
Peter R Flanagan +2 more
exaly +3 more sources
High efficacy therapy to prevent the formation of meningeal tertiary lymphoid organs after CXCL13 index screening in early multiple sclerosis [PDF]
Frontiers in NeurosciencePostmortem studies have shown the presence of subpial inflammation with tertiary lymphoid organs (TLO) in the meninges of patients with progressive multiple sclerosis, playing an important role in the pathophysiology of the disease.
Ana C. Londoño +2 more
doaj +2 more sources
Microbiology (United Kingdom)Candida albicans uniquely possesses an expanded family of genes (the TLO gene family) that encodes 10–15 paralogues of the Med2 component of the transcriptional regulator Mediator.
James O'Connor-Moneley +2 more
exaly +3 more sources
Transportation and logistics observatories: Guidelines for a conceptual model
Transportation Research Interdisciplinary Perspectives, 2022 A conceptual model should illustrate the most significant concepts of a given problem domain and demonstrate relevant aspects related to that domain. In this paper, a conceptual model for a Transportation and Logistics Observatory (TLO) is proposed along
Lilian Campos Soares +2 more
doaj +1 more source
Utjecaj pH vrijednosti tla i dodatka kelatnog agensa na sadržaj kadmija u pojedinim biljkama [PDF]
Kemija u Industriji, 2016 U ovom je radu ispitivan utjecaj pH tla i dodatka kompleksirajućeg agensa na sadržaj kadmija u pojedinim biljkama. Tlo upotrijebljeno za ovaj eksperiment uzeto je s površina uz prometnicu u neposrednoj blizini Željezare u Zenici.
Farzet Bikić, Amira Pašalić
doaj +1 more source
Development of Flow Type Cesium Removing Device Using Fluorinated Solvent [PDF]
MATEC Web of Conferences, 2021 In order to simultaneously achieve separation and volume reduction of radioactive cesium in the aqueous solution, we proposed a solvent extraction using a fluorinated solvent which is a nonflammable liquid having a low boiling point and is easy to ...
Suzuki Motoshi +4 more
doaj +1 more source
BMJ Open Ophthalmology, 2020 Objective To compare the 1-year outcomes of trabeculotomy ab externo (ab externo TLO) and trabeculotomy ab interno using a microhook (ab interno TLO) for glaucoma patients using propensity score analysis.Methods and analysis The medical charts of 65 ...
Sotaro Mori +6 more
doaj +1 more source
Amplification of TLO Mediator Subunit Genes Facilitate Filamentous Growth in Candida Spp. [PDF]
PLoS Genetics, 2016 Filamentous growth is a hallmark of C. albicans pathogenicity compared to less-virulent ascomycetes. A multitude of transcription factors regulate filamentous growth in response to specific environmental cues. Our work, however, suggests the evolutionary
Zhongle Liu +4 more
doaj +1 more source