Results 271 to 280 of about 152,328 (305)

The double life of TLR2

Science Signaling, 2021
TLR2 located in the endothelium promotes angiogenesis and inflammation.
Samantha Mahfoud, Tatiana V. Petrova
openaire   +2 more sources

TLR2 in murine atherosclerosis

Seminars in Immunopathology, 2007
Atherosclerosis was once thought to be solely a disease of lipid accumulation in the vessel wall. It does involve lipid accumulation, but inflammation appears to be an important driving factor. Consequently, our laboratory undertook to examine the role(s) of TLRs, and especially TLR2, in murine models of atherosclerosis.
Peter S, Tobias, Linda K, Curtiss
openaire   +2 more sources

Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2015
SignificanceExcess Toll-like receptor 2 (TLR2) signaling has been implicated in numerous inflammatory diseases, yet there is no TLR2 inhibitor licensed for human use. Using computer-aided drug design (CADD), we identified a compound, C16H15NO4(C29), and a derivative,ortho-vanillin, that inhibit TLR2 signaling in vitro and in vivo.
Greg A Snyder, Tsan Sam Xiao, Jay Chauhan   +2 more
exaly   +3 more sources

Lipid-associated membrane lipopeptides of M. arginini activate NF-κB by interacting with TLR2/1, TLR2/6, and TLR2/CD14

Molecular Genetics, Microbiology and Virology, 2009
Various strains of mycoplasmas cause activation of transcriptional factor NF-kB as a result of interaction with different combinations of Toll-like receptors (TLR). It is well known that the MALP-2 protein of M. fermentans activates the NF-kB through interaction with the TLR2/6, lipid-associated membrane lipopeptides (LAMPs) of M. penetrans through the
D Iu, Logunov, D V, Shchebliakov, O V, Zubkova, M M, Shmarov, I V, Rakovskaia, L A, Gintsburg, A V, Gudkov, B S, Naroditskiĭ   +7 more
openaire   +2 more sources

TLR2 tolerance in EAE

The Journal of Immunology, 2016
Abstract TLR2 expression is enhanced in MS and EAE, but its role in these diseases is controversial. In adoptive transfer EAE, exogenous TLR ligands are not administered yet TLR2-deficient mice have been reported to develop attenuated disease. Despite this evidence for a disease-promoting function of TLR2, others have shown the opposite,
Emily J Anstadt, Mai Fujiwara, Frank Nichols, Robert B Clark   +3 more
openaire   +1 more source

Rare TLR2 mutations reduce TLR2 receptor function and can increase atopy risk

Allergy, 2009
Background:  Common genetic variations in toll‐like receptor 2 (TLR2), an innate pathogen recognition receptor, may influence the development of atopic diseases. So far, very little is known about the role of rare TLR2 mutations in these diseases.Objective:  We investigated the functional properties of six rare amino acid changes in TLR2 (and one amino
M S D, Kormann, R, Ferstl, M, Depner, N, Klopp, S, Spiller, T, Illig, C, Vogelberg, E, von Mutius, C J, Kirschning, M, Kabesch   +9 more
openaire   +2 more sources

TLR2 agonists and their structure–activity relationships

Organic & Biomolecular Chemistry, 2020
We review the structure–activity relationships and synthetic studies of TLR2 agonists – important chemical targets in immunotherapy.
Benjamin L. Lu, Geoffrey M. Williams, Margaret A. Brimble   +2 more
openaire   +2 more sources

TLR2 Arg677Trp polymorphism in leprosy: revisited

Human Genetics, 2005
We investigated the Toll-like receptor 2 (TLR2) Arg677Trp polymorphism, associated with lepromatous leprosy in the Korean population and shown to abrogate TLR2-mediated signalling in response to mycobacterial ligands, in 286 Indian leprosy patients and 183 ethnically matched controls.
Dheeraj, Malhotra, Vineet, Relhan, B S N, Reddy, Ramesh, Bamezai   +3 more
openaire   +2 more sources

The Noninflammatory Side of TLR2

Science Signaling, 2012
Toll-like receptor 2 promotes tumorigenesis in a mouse model of gastric cancer, but not by enhancing inflammation.
openaire   +1 more source

R753Q polymorphism compromises TLR2 signaling functions by altering TLR6-TLR2 hetero-dimerization, TLR2 tyrosine phosphorylation and MyD88 recruitment (180.2)

The Journal of Immunology, 2012
Abstract TLR2 senses lipoproteins expressed by Gram positive bacteria, mycoplasma, mycobacteria and fungi. The Arg753Gln (R753Q) polymorphism in the TIR domain of TLR2 has been linked to increased incidence of tuberculosis, leprosy and other diseases. But the molecular mechanisms by which it affects TLR2 functions are unclear.
Yanbao Xiong, Chang Song, Andrei Medvedev   +2 more
openaire   +1 more source