Results 221 to 230 of about 45,202 (234)

Antiviral responses induced by the TLR3 pathway

Reviews in Medical Virology, 2011
AbstractAntiviral responses are successively induced in virus‐infected animals, and include primary innate immune responses such as type I interferon (IFN) and cytokine production, secondary natural killer (NK) cell responses, and final cytotoxic T lymphocyte (CTL) responses and antibody production.
Misako, Matsumoto, Hiroyuki, Oshiumi, Tsukasa, Seya   +2 more
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STRAP positively regulates TLR3-triggered signaling pathway

Cellular Immunology, 2017
Toll-like receptor (TLR) signaling drives the innate immune response by activating nuclear factor-κB (NF-κB) and interferon regulatory factor (IRF). We have previously shown that STRAP interacts with TAK1 and IKKα along with NF-κB subunit p65, leading to the activation of pro-inflammatory cytokines.
Hyunbin D, Huh, Eunhye, Lee, Jinwook, Shin, Boyoun, Park, Sungwook, Lee   +4 more
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TLR3 plays significant roles against hepatitis B virus

Molecular Biology Reports, 2014
Hepatitis B virus (HBV) as the main prevalent infectious agent, play important roles in inducing severe liver diseases. Previous studies demonstrated that during prolonged forms of hepatitis B infection including chronic, asymptomatic and occult forms, patients are unable to eradicate HBV from hepatocytes completely. The main mechanisms responsible for
Masoud, Karimi-Googheri, Mohammad Kazemi, Arababadi   +1 more
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TLR3 Deficiency in Patients with Herpes Simplex Encephalitis

Science, 2007
Some Toll and Toll-like receptors (TLRs) provide immunity to experimental infections in animal models, but their contribution to host defense in natural ecosystems is unknown. We report a dominant-negative TLR3 allele in otherwise healthy children with herpes simplex virus 1 (HSV-1) encephalitis.
Zhang, Shen-Ying, Jouanguy, Emmanuelle, Ugolini, Sophie, Smahi, Asma, Elain, Gaëlle, Romero, Pedro, Segal, David, Sancho-Shimizu, Vanessa, Lorenzo, Lazaro, Puel, Anne, Picard, Capucine, Chapgier, Ariane, Plancoulaine, Sabine, Titeux, Matthias, Cognet, Céline, von Bernuth, Horst, Ku, Cheng-Lung, Casrouge, Armanda, Zhang, Xin-Xin, Barreiro, Luis, Leonard, Joshua, Hamilton, Claire, Lebon, Pierre, Héron, Bénédicte, Vallée, Louis, Quintana-Murci, Lluis, Hovnanian, Alain, Rozenberg, Flore, Vivier, Eric, Geissmann, Frédéric, Tardieu, Marc, Abel, Laurent, Casanova, Jean-Laurent   +32 more
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The molecular structure of the TLR3 extracellular domain

Journal of Endotoxin Research, 2006
Toll-like receptors (TLRs), type I integral membrane receptors, recognize pathogen associated molecular patterns (PAMPs). PAMP recognition occurs via the N-terminal ectodomain (ECD) which initiates an inflammatory response that is mediated by the C-terminal cytosolic signaling domain.
Jessica K, Bell, Istvan, Botos, Pamela R, Hall, Janine, Askins, Joseph, Shiloach, David R, Davies, David M, Segal   +6 more
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Investigating the TLR3 Signaling Dynamics

2013
Along with TLR-7, -8, and -9, TLR3 is an intracellular member of the Toll-like receptor (TLR) superfamily (see Chap. 3). It plays a crucial role in the mammalian innate immune response against viral attacks by recognizing double-stranded RNA (dsRNA) or its synthetic analogue polyinosinic-polycytidylic acid (poly (I:C)).
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TLR3 Agonists as Immunotherapeutic Agents

Immunotherapy, 2010
Christopher F, Nicodemus, Jonathan S, Berek   +1 more
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TLR3 Deficiency

2018
Henry Y. Lu, Stuart E. Turvey
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Endocannabinoid modulation of TLR3-induced neuroinflammation

2017
Toll-like receptors (TLRs) play a key role in the recognition and activation of the innate immune system in response to infection. However, aberrant TLR activation has been implicated in predisposing to, and exacerbating, the pathological processes underlying a number of neuroinflammatory disorders.
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TLR3 and skin features

Current Research in Translational Medicine, 2016
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