Results 311 to 320 of about 272,563 (343)

Cigarette Smoke Upregulates TLR4 Expression and Enhances TLR4 Mediated Responses

2006
A key component of the innate defence mecbanisms against infections is represented by the tolllike receptor (TLR) family. We explored the role played by TLR4 in the pathogenesis of chronic obstructive pulmonary disease (COPD). We first assessed TLR4 expression by immunohystochemistry in surgical specimens from current and former smoker COPDs, from ...
PACE E, FERRARO M, MINERVINI MI, CHIAPPARA G, SIENA L, PIPITONE L, MELIS MR, MONTALBANO AM, BONSIGNORE MR, BELLIA V, BONSIGNORE G, GJOMARKAJ M   +11 more
openaire   +3 more sources

Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats.

Experimental Neurology, 2021
Kaiyi Zhu, Xing Zhu, Shenghui Sun, Wei Yang, Shiqi Liu, Zhen Tang, Rong Zhang, Jian Li, Tao Shen, M. Hei   +9 more
semanticscholar   +1 more source

Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene.

Science, 1998
A. Poltorak, Xiaolong He, I. Smirnova, Mu-ya Liu, C. Huffel, Xin Du, D. Birdwell, Erica Alejos, Maria Silva, C. Galanos, M. Freudenberg, P. Ricciardi-Castagnoli, Betsy Layton, B. Beutler   +13 more
semanticscholar   +1 more source

TLR4 and LPS hyporesponsiveness in humans

International Journal of Hygiene and Environmental Health, 2002
Asthma is a complex genetic disorder that is caused by a number of unique gene-gene and gene-environment interactions. The search for asthma susceptibility genes has been complicated by the broad clinical phenotype of asthma, the polygenic inheritance pattern of this disease, and the substantial role of environmental exposures in the development and ...
openaire   +2 more sources

??????????????? ?????????????????????????? ?????????? TLR2 ???? TLR4 ???? ???????????????????? ???? ?????????????? ???????????????????????????? ????????????????

2014
???????????????????? ?????????????????????? ???????????????????????????????? ?????????????????????? ?????????????????? Arg753Gln ???????? TLR2 ???? Asp299Gly, Thr399Ile ???????? TLR4 ?????????? ????????, ???? ???????????????????? ?? ?????????????????????? ??????????????, ?? ?????????? ??????????????? ?????????????????????????? ???? ?????????????????? ??
openaire   +1 more source

Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson's disease mice: Gut microbiota, glial reaction and TLR4/TNF-α signaling pathway.

Brain, behavior, and immunity, 2018
Mengfei Sun, Ying-li Zhu, Zhilan Zhou, Xuebing Jia, Yi-Da Xu, Qin Yang, Chun Cui, Yan-Qin Shen   +7 more
semanticscholar   +1 more source

TLR4 as the Mammalian Endotoxin Sensor

2002
For more than a century, the ability to sense endotoxin (later known also as lipopolysaccharide; LPS) stood as the archetypal innate immune response: even before the phrase 'innate immunity' became popular. Yet the mechanism by which LPS initiated a signal remained unknown.
openaire   +2 more sources

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

Science, 2013
N. Kayagaki, M. Wong, Irma B. Stowe, S. R. Ramani, Lino C. Gonzalez, Sachiko Akashi-Takamura, K. Miyake, Juan Zhang, Wyne P. Lee, Artur Muszyński, L. S. Forsberg, R. Carlson, V. Dixit   +12 more
semanticscholar   +1 more source

TLR4

2012
openaire   +2 more sources

TLR4

2014
openaire   +1 more source