Results 201 to 210 of about 18,028 (232)

MicroRNA-494-3p alleviates inflammatory response in sepsis by targeting TLR6.

European review for medical and pharmacological sciences, 2019
To clarify whether microRNA-494-3p could exert an anti-inflammation effect by suppressing the expression of toll-like receptor 6 (TLR6), thus inhibiting the development of sepsis.Plasma levels of microRNA-494-3p and TLR6 in sepsis patients and healthy controls were determined by quantitative real-time polymerase chain reaction (qRT-PCR).
H-F Wang, Y. Li, Y. Wang, H.-J. Li, L. Dou   +4 more
semanticscholar   +3 more sources

Mycobacterial Infection in TLR2 and TLR6 Knockout Mice [PDF]

Microbiology and Immunology, 2003
AbstractTo investigate the role of TLR in the development of murine tuberculosis in vivo, TLR2 and TLR6 knockout (KO) mice were infected with Mycobacterium tuberculosis by placing them in the exposure chamber of an airborne infection apparatus. Both TLR2 and TLR6 KO mice survived until sacrifice at 12 weeks after infection.
Hiroyuki Yamada, Osamu Takeuchi, Shizuo Akira   +2 more
exaly   +3 more sources

TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides [PDF]

Journal of Biological Chemistry, 2006
Bacterial cell walls contain lipoproteins/peptides, which are strong modulators of the innate immune system. Triacylated lipopeptides are assumed to be recognized by TLR2/TLR1-, whereas diacylated lipopeptides use TLR2/TLR6 heteromers for signaling. Following our initial discovery of TLR6-independent diacylated lipopeptides, we could now characterize ...
Holger Heine, Roland Brock, Shizuo Akira
exaly   +4 more sources

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Interaction of ectodomain of Respiratory Syncytial Virus G protein with TLR2/TLR6 heterodimer: An in vitro and in silico approach to decipher the role of RSV G protein in pro-inflammatory response against the virus.

Current pharmaceutical design, 2021
BACKGROUND The human respiratory syncytial virus (RSV) has been linked with various respiratory diseases such as common cold to lower respiratory tract illnesses like pneumonia and bronchiolitis.
K. Alshaghdali, Mohd Saeed, M. Kamal, A. Saeed   +3 more
semanticscholar   +1 more source

A TLR6 polymorphism is associated with increased risk of Legionnaires’ disease [PDF]

Genes and Immunity, 2013
Legionella pneumophila (Lp), the etiologic agent of Legionnaires' disease (LD), is an important cause of community-acquired and nosocomial pneumonia. However, the host immune and genetic determinants of human susceptibility to Lp are poorly understood. Here we show that both TLR6 and TLR1 cooperate with TLR2 to recognize Lp in transfected HEK293 cells.
Misch, E. A., Verbon, A., Prins, J. M., Skerrett, S. J., Hawn, T. R.   +4 more
exaly   +5 more sources

Baicalin ameliorates Mycoplasma gallisepticum-induced lung inflammation in chicken by inhibiting TLR6-mediated NF-κB signalling

British Poultry Science, 2020
1. Mycoplasma gallisepticum (MG) causes severe lung inflammation and cell damage by activating toll-like receptor (TLR) signalling, the nuclear factor-kappaB (NF-κB) pathway and pro-inflammatory cytokine gene expression.
M. Zou, L. Yang, L. Niu, Y. Zhao, Y. Sun, Y. Fu, X. Peng   +6 more
semanticscholar   +1 more source

Polydatin attenuates Mycoplasma gallisepticum (HS strain)-induced inflammation injury via inhibiting the TLR6/ MyD88/NF-κB pathway.

Microbial Pathogenesis, 2020
Mycoplasma gallisepticum (MG) infection is the main cause of chronic respiratory disease (CRD) characterized by severe respiratory inflammation in chickens. Polydatin (PD) is a resveratrol glycoside isolated from Polygonum cuspidatum, which has prominent
M. Zou, Wenlong Yang, Lumeng Niu, Yingfei Sun, R. Luo, Yingjie Wang, Xiuli Peng   +6 more
semanticscholar   +1 more source

MMP9, CXCR1, TLR6, and MPO participant in the progression of coronary artery disease

Journal of Cellular Physiology, 2020
Coronary artery disease (CAD) is the most frequent cardiovascular disease, which is induced by the decreased myocardial blood supply. The present study is conducted to understand the mechanisms of CAD.
Che Wang, Qingmin Li, Honghui Yang, Chuanyu Gao, Q. Du, Caili Zhang, Lijie Zhu, Qingman Li   +7 more
semanticscholar   +1 more source

Association of TLR1, TLR2, TLR4, TLR6, and TIRAP polymorphisms with disease susceptibility

Immunologic Research, 2015
Toll like receptors (TLRs) play a crucial role in regulation of innate as well as adaptive immunity. TLRs recognize a distinct but limited repertoire of conserved microbial products. Ligand binding to TLRs activates the signaling cascade and results in activation of multiple inflammatory genes. Variation in this immune response is under genetic control.
M. Noreen, Muhammad Arshad
semanticscholar   +3 more sources

TLR6: A novel member of an expanding Toll-like receptor family

Gene, 1999
Drosophila Toll protein is shown to activate the innate immune system in adult and regulate the dorsoventral patterning in the developing embryo. Recently, five human homologs of Drosophila Toll, designated as Toll-like receptors (TLRs), have been identified and shown to play a role in the innate immune response.
O, Takeuchi, T, Kawai, H, Sanjo, N G, Copeland, D J, Gilbert, N A, Jenkins, K, Takeda, S, Akira   +7 more
openaire   +2 more sources