Results 151 to 160 of about 1,421 (164)
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Mechanisms of Sigma‐2/TMEM97 Involvement in Cholesterol Metabolism
Journal of Cellular BiochemistryABSTRACTExtensive research has focused on cellular cholesterol and its regulation, primarily due to its crucial physiological roles and its association with numerous diseases resulting from dysregulated homeostasis. Consequently, investigating cholesterol metabolism and the network of regulating proteins remains an ongoing challenge for biomedical ...
Martina Parente +4 more
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Human Cell, 2022
Transmembrane protein 97 (TMEM97) is a conserved integral membrane protein highly expressed in various human cancers, including colorectal cancer (CRC), and it exhibits pro-tumor roles in breast cancer, gastric cancer, and glioma. However, whether TMEM97 participates in CRC progression is not fully understood.
Dong Mao +4 more
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Transmembrane protein 97 (TMEM97) is a conserved integral membrane protein highly expressed in various human cancers, including colorectal cancer (CRC), and it exhibits pro-tumor roles in breast cancer, gastric cancer, and glioma. However, whether TMEM97 participates in CRC progression is not fully understood.
Dong Mao +4 more
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Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2021
The expression of TMEM97, a regulator of cholesterol transport, has been reported to be enhanced in some tumour cells. We have recently shown that TMEM97 is involved in the proliferation of the breast cancer cell line MDA-MB-231, probably through changes in store-operated calcium entry (SOCE).
Cantonero Chamorro, Carlos +4 more
exaly +4 more sources
The expression of TMEM97, a regulator of cholesterol transport, has been reported to be enhanced in some tumour cells. We have recently shown that TMEM97 is involved in the proliferation of the breast cancer cell line MDA-MB-231, probably through changes in store-operated calcium entry (SOCE).
Cantonero Chamorro, Carlos +4 more
exaly +4 more sources
Abstract TP380: TMEM97 and Lipid Metabolism: Unraveling Post-Stroke Lipid Regulation
StrokeRecent research on neurodegenerative diseases has highlighted a pathophysiological cascade characterized by abnormal lipid accumulation within the brain. Although progress has been made, the role of lipid metabolism following stroke remains unclear. This study aims to further explore changes in lipid metabolism after stroke, with a specific focus on ...
Kajsa Arkelius +5 more
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Cancer Research, 2018
Abstract Introduction: Breast cancer is the most prevalent cancer for women both in the developed and the developing countries. In 2017, about 40,610 women are expected to die from breast cancer in the U.S. The sigma receptors (σRs) are transmembrane receptors with two subtypes, termed sigma-1 receptor and sigma-2 receptor.
Yuanqin Zhang, Jiuhui Wang, Daotai Nie
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Abstract Introduction: Breast cancer is the most prevalent cancer for women both in the developed and the developing countries. In 2017, about 40,610 women are expected to die from breast cancer in the U.S. The sigma receptors (σRs) are transmembrane receptors with two subtypes, termed sigma-1 receptor and sigma-2 receptor.
Yuanqin Zhang, Jiuhui Wang, Daotai Nie
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Neurosurgery
INTRODUCTION: Early brain injury (EBI) has been confirmed as the primary determinant of poor outcomes in SAH. Cell apoptosis and oxidative stress may be critical to the development of EBI. Excessive mitochondrial fission directly induces in cell oxidative stress and apoptosis.
Shuai Lan +6 more
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INTRODUCTION: Early brain injury (EBI) has been confirmed as the primary determinant of poor outcomes in SAH. Cell apoptosis and oxidative stress may be critical to the development of EBI. Excessive mitochondrial fission directly induces in cell oxidative stress and apoptosis.
Shuai Lan +6 more
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The FASEB Journal
ABSTRACT The occurrence of oxidative stress and apoptosis is closely associated with early brain injury (EBI) following subarachnoid hemorrhage (SAH). Currently, there is a lack of effective therapeutic targets or specific pharmacological agents to counteract oxidative stress and cell death after SAH.
Bowen Sun +14 more
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ABSTRACT The occurrence of oxidative stress and apoptosis is closely associated with early brain injury (EBI) following subarachnoid hemorrhage (SAH). Currently, there is a lack of effective therapeutic targets or specific pharmacological agents to counteract oxidative stress and cell death after SAH.
Bowen Sun +14 more
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Arteriosclerosis, Thrombosis, and Vascular Biology
BACKGROUND: The aims of this study were to evaluate σ 2 R (sigma-2 receptor)/TMEM97 (transmembrane protein 97) expression in atherosclerotic plaques, and assess the feasibility of in vivo atherosclerotic plaques imaging using the σ 2 R/TMEM97 targeting probe
Tiantian Mou +10 more
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BACKGROUND: The aims of this study were to evaluate σ 2 R (sigma-2 receptor)/TMEM97 (transmembrane protein 97) expression in atherosclerotic plaques, and assess the feasibility of in vivo atherosclerotic plaques imaging using the σ 2 R/TMEM97 targeting probe
Tiantian Mou +10 more
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Therapeutic targeting in colorectal cancer for the treatment of the primary tumor: TMEM97.
Colorectal cancer results in nearly 1,000,000 deaths each year (1-5). We recently utilized whole transcriptome technologies to define the full complement of differentially expressed kinases and phosphatases in HER2+ breast cancer: in the primary tumor, and in metastasis to the CNS (6-8).openaire +1 more source
The Role Of Sigma-2/TMEM97 In The Context Of Affective And Pain Behaviors
The Journal of Pain, 2023Veronica Hong +6 more
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