Results 191 to 200 of about 43,824 (207)

Differential modulation of SARS-CoV-2 infection by complement factor H and properdin. [PDF]

Front Immunol
Kishore U, Varghese PM, Kumar C, Idicula-Thomas S, Mayora Neto M, Tsolaki AG, Ponnachan P, Masmoudi K, Al-Ramadi B, Vatish M, Madan T, Temperton N, Beirag N.   +12 more
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An orally available M^pro/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo. [PDF]

Nat Commun
Shuai H, Qiao J, Yoon C, Zhang G, Hou Y, Xia X, Wang L, Deng X, Wang Y, Li Q, Du L, Liu Y, Zhou M, Wong HT, Hu J, Liu H, Hu B, Wang D, Su J, Pan Y, Ye Y, Chen Y, Fang Z, Xia Z, Chai Y, Shi J, Wang Y, Zhu T, Zhang H, Yuan S, Zhou J, Chan JF, Yuen KY, Xu C, Lei J, Yang S, Chu H.   +36 more
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TMPRSS2 fusions in prostate cancer

Diagnostic Histopathology, 2008
Abstract The discovery of TMPRSS2 fusions in prostate is the most significant advance in the molecular pathology of prostate cancer in the past 10 years. In the 2 years since this discovery was first described there has been a large amount of research investigating the detailed mechanisms, prognostic significance and diagnostic utility of these ...
Simon S. Cross, Ishtiaq. Rehman, Freddie.C. Hamdy, Chitra. Sethuraman, John.R. Goepel, Edna. Maltby   +5 more
openaire   +1 more source

TMPRSS2 Activates Hemagglutinin-Esterase Glycoprotein of Influenza C Virus

Journal of Virology, 2021
Influenza C virus (ICV) is a pathogen that causes acute respiratory illness, mostly in children, but there are no anti-ICV drugs. ICV has only one kind of spike protein, the hemagglutinin-esterase (HE) glycoprotein on the virion surface, which possesses receptor-binding, receptor-destroying, and membrane fusion activities.
Ko Sato, Hideki Hayashi, Yoshitaka Shimotai, Mutsuo Yamaya, Seiji Hongo, Kazuyoshi Kawakami, Yoko Matsuzaki, Hidekazu Nishimura   +7 more
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Die TMPRSS2-ETS-Genfusion beim Prostatakarzinom

Der Urologe, 2007
Hintergrund Bisher galten rekurrente Translokationen und Genfusionen bei den sehr haufigen epithelialen Tumoren als ein seltenes Ereignis. Uberraschenderweise hat unsere Arbeitsgruppe vor kurzem mittels eines neuen bioinformatischen Ansatzes eine neuartige Genfusion beim Prostatakarzinom identifiziert.
S. Perner, F.H. Schmidt, M.D. Hofer, R. Kuefer, M. Rubin   +4 more
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Optimizing the pharmacokinetics and selectivity of TMPRSS2 inhibitors

European Journal of Medicinal Chemistry
Since 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone significant genomic mutations, contributing to resistance against existing 2019 coronavirus disease (COVID-19) treatments. In a previous study, we identified N-0385, a potent host-directed inhibitor of transmembrane serine protease 2 (TMPRSS2), which has therapeutic ...
Sára Ferková, Matthieu Lepage, Antoine Désilets, Kevin Assouvie, Gabriel Lemieux, Isabelle Brochu, Ulrike Froehlich, Alice Gravel-Trudeau, Jules Vastra, François Jean, Philippe Sarret, Richard Leduc, Pierre-Luc Boudreault   +12 more
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TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry

Cell
The entry of coronaviruses is initiated by spike recognition of host cellular receptors, involving proteinaceous and/or glycan receptors. Recently, TMPRSS2 was identified as the proteinaceous receptor for HCoV-HKU1 alongside sialoglycan as a glycan receptor. However, the underlying mechanisms for viral entry remain unknown.
Haofeng Wang, Xiaoce Liu, Xiang Zhang, Zhuoqian Zhao, Yuchi Lu, Dingzhe Pu, Zeyang Zhang, Jie Chen, Yajie Wang, Mengfei Li, Xuxue Dong, Yinkai Duan, Yujia He, Qiyu Mao, Hangtian Guo, Haoran Sun, Yihan Zhou, Qi Yang, Yan Gao, Xiuna Yang, Hongzhi Cao, Luke Guddat, Lei Sun, Zihe Rao, Haitao Yang   +24 more
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Characterize the difference between TMPRSS2-ERG and non-TMPRSS2-ERG fusion patients by clinical and biological characteristics in prostate cancer

Gene, 2018
The TMPRSS2-ERG gene fusion were frequently found in prostate cancer, and thought to play some fundamental mechanisms for the development of prostate cancer. However, until now, the clinical and prognostic significance of TMPRSS2-ERG gene fusion was not fully understood.
Shiyuan, Wang, Qi, Zhang, Dandan, Xu, Yi, Pan, Yingli, Lv, Xiaowen, Chen, Yongchun, Zuo, Lei, Yang   +7 more
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Protocols for Studies on TMPRSS2/ERG in Prostate Cancer

2018
TMPRSS2/ERG is the most common type of gene fusions found in human prostate cancer. There are two important features of TMPRSS2/ERG fusions. One is that these gene fusions lead to ectopic expression of ERG, an ETS family transcription factor, in prostate epithelial cells from the 5' control region of an androgen/estrogen dual-responsive gene, TMPRSS2 ...
Hubert, Pakula, Douglas E, Linn, Daniel R, Schmidt, Marit, Van Gorsel, Matthew G, Vander Heiden, Zhe, Li   +5 more
openaire   +2 more sources