Results 191 to 200 of about 31,965 (231)

SAMHD1 depletion restricts SARS-CoV-2 infection by suppressing HNF1-dependent ACE2 expression in lung epithelial cells. [PDF]

PLoS Pathog
Cheung PH, Chan P, Yang H, Ambrus K, Honne S, Kim B, Perlman S, Wu L.   +7 more
europepmc   +1 more source

TMPRSS2 Expression in Lung Tissue of Prostatic Adenocarcinoma Patients: Androgen Deprivation Therapy and Relevance to SARS-CoV-2 Infection. [PDF]

Curr Issues Mol Biol
Riveros Angel M, Loeffler D, Charifa A, Sinit RB, Amery T, Cengiz B, Beer TM, Thomas GV.   +7 more
europepmc   +1 more source

Mechanistic evaluation of the in vitro antiviral and anti-inflammatory potential of thyme and licorice herbal preparation. [PDF]

Sci Rep
Karadağ AE, Baydar R, Demirci F.
europepmc   +1 more source

Targeting envelope lipids with 2,6‑di‑<i>O</i>‑methyl‑3‑acetyl‑β‑cyclodextrin impairs infectivity of SARS‑CoV‑2 and Japanese encephalitis virus. [PDF]

J Virol
Kusakari D, Kishimoto N, Oshiro K, Udeda Y, Takamune N, Motoyama K, Misumi S.   +6 more
europepmc   +1 more source

Furin as a Novel Pan-Viral Therapeutic Target: Implications for Dengue and SARS-CoV-2. [PDF]

Viruses
Shalaby L, Al-Haneedi Y, Abdelhamid A, Yassine H, Emara MM.   +4 more
europepmc   +1 more source

The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment [PDF]

International Journal of Molecular Sciences, 2022
TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of the respiratory and gastrointestinal tract, the prostate, and other organs.
Munch Jan, Frank Kirchhoff, Frank Kirchhoff   +2 more
exaly   +2 more sources

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TMPRSS2 fusions in prostate cancer

Diagnostic Histopathology, 2008
Abstract The discovery of TMPRSS2 fusions in prostate is the most significant advance in the molecular pathology of prostate cancer in the past 10 years. In the 2 years since this discovery was first described there has been a large amount of research investigating the detailed mechanisms, prognostic significance and diagnostic utility of these ...
Simon S. Cross, Ishtiaq. Rehman, Freddie.C. Hamdy, Chitra. Sethuraman, John.R. Goepel, Edna. Maltby   +5 more
openaire   +1 more source

Human coronavirus HKU1 recognition of the TMPRSS2 host receptor [PDF]

Cell
: The human coronavirus HKU1 spike (S) glycoprotein engages host cell surface sialoglycans and transmembrane protease serine 2 (TMPRSS2) to initiate infection.
David Veesler, Jack Brown
exaly   +1 more source

Diversity of TMPRSS2-ERG fusion transcripts in the human prostate [PDF]

Oncogene, 2006
TMPRSS2-ERG gene fusions have recently been reported to be present in a high proportion of human prostate cancers. In the current study, we show that great diversity exists in the precise structure of TMPRSS2-ERG hybrid transcripts found in human ...
Francis L Martin, Kovacs G, Thompson A
exaly   +2 more sources

Optimizing the pharmacokinetics and selectivity of TMPRSS2 inhibitors

European Journal of Medicinal Chemistry
Since 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone significant genomic mutations, contributing to resistance against existing 2019 coronavirus disease (COVID-19) treatments. In a previous study, we identified N-0385, a potent host-directed inhibitor of transmembrane serine protease 2 (TMPRSS2), which has therapeutic ...
Sára Ferková, Matthieu Lepage, Antoine Désilets, Kevin Assouvie, Gabriel Lemieux, Isabelle Brochu, Ulrike Froehlich, Alice Gravel-Trudeau, Jules Vastra, François Jean, Philippe Sarret, Richard Leduc, Pierre-Luc Boudreault   +12 more
openaire   +2 more sources