Results 191 to 200 of about 33,857 (224)

TMPRSS2 fusions in prostate cancer

Diagnostic Histopathology, 2008
Abstract The discovery of TMPRSS2 fusions in prostate is the most significant advance in the molecular pathology of prostate cancer in the past 10 years. In the 2 years since this discovery was first described there has been a large amount of research investigating the detailed mechanisms, prognostic significance and diagnostic utility of these ...
Simon S. Cross, Ishtiaq. Rehman, Freddie.C. Hamdy, Chitra. Sethuraman, John.R. Goepel, Edna. Maltby   +5 more
openaire   +1 more source

Optimizing the pharmacokinetics and selectivity of TMPRSS2 inhibitors

European Journal of Medicinal Chemistry
Since 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone significant genomic mutations, contributing to resistance against existing 2019 coronavirus disease (COVID-19) treatments. In a previous study, we identified N-0385, a potent host-directed inhibitor of transmembrane serine protease 2 (TMPRSS2), which has therapeutic ...
Sára Ferková, Matthieu Lepage, Antoine Désilets, Kevin Assouvie, Gabriel Lemieux, Isabelle Brochu, Ulrike Froehlich, Alice Gravel-Trudeau, Jules Vastra, François Jean, Philippe Sarret, Richard Leduc, Pierre-Luc Boudreault   +12 more
openaire   +2 more sources

Diversity of TMPRSS2-ERG fusion transcripts in the human prostate

Oncogene, 2006
TMPRSS2-ERG gene fusions have recently been reported to be present in a high proportion of human prostate cancers. In the current study, we show that great diversity exists in the precise structure of TMPRSS2-ERG hybrid transcripts found in human ...
Francis L Martin, P Flohr, C Fisher
exaly   +2 more sources

Protocols for Studies on TMPRSS2/ERG in Prostate Cancer

2018
TMPRSS2/ERG is the most common type of gene fusions found in human prostate cancer. There are two important features of TMPRSS2/ERG fusions. One is that these gene fusions lead to ectopic expression of ERG, an ETS family transcription factor, in prostate epithelial cells from the 5' control region of an androgen/estrogen dual-responsive gene, TMPRSS2 ...
Hubert, Pakula, Douglas E, Linn, Daniel R, Schmidt, Marit, Van Gorsel, Matthew G, Vander Heiden, Zhe, Li   +5 more
openaire   +2 more sources

Characterize the difference between TMPRSS2-ERG and non-TMPRSS2-ERG fusion patients by clinical and biological characteristics in prostate cancer

Gene, 2018
The TMPRSS2-ERG gene fusion were frequently found in prostate cancer, and thought to play some fundamental mechanisms for the development of prostate cancer. However, until now, the clinical and prognostic significance of TMPRSS2-ERG gene fusion was not fully understood.
Shiyuan, Wang, Qi, Zhang, Dandan, Xu, Yi, Pan, Yingli, Lv, Xiaowen, Chen, Yongchun, Zuo, Lei, Yang   +7 more
openaire   +2 more sources

The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment

International Journal of Molecular Sciences, 2022
Jan Münch, Frank Kirchhoff, Frank Kirchhoff   +2 more
exaly  

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Cell, 2020
Stefan Pöhlmann, Tobias S Schiergens, Andreas Nitsche   +2 more
exaly  

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

EBioMedicine, 2021
Stefan Pöhlmann, Olga Danov, Ole Schmeltz Søgaard   +2 more
exaly  

TMPRSS2 Gene

2020
openaire   +1 more source

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells

Cell Metabolism, 2020
Roland Stein, Meghan E. Kapp, Klaus H. Kaestner   +2 more
exaly