Results 41 to 50 of about 1,432,152 (227)

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Stable snowmelt supply dominates enhanced runoff stability in the Tianshan Mountains of Central Asia

Journal of Hydrology: Regional Studies
Study region: This study focuses on 89 basins in the Tianshan Mountains (TMs). Study focus: The strength of seasonal cycle (R) from recently developed Directional Statistics method was employed to quantify the changes in runoff stability (Rrunoff) in the
Xueyan Qin, Xiuliang Yuan, Rafiq Hamdi, Jie Bai, Philippe De Maeyer, Hossein Tabari   +5 more
doaj   +1 more source

TMS as a rehabilitation technique for cocaine addiction [PDF]

, 2022
openQuesto lavoro vuole indagare se è possibile impiegare la stimolazione magnetica transcranica ripetitiva (repetitive trascranial magnetic stimulation-rTMS) nel trattamento della dipendenza da cocaina.
CARABBA, FRANCESCO
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Interventional Psychiatry and Emerging Treatments for Posttraumatic Stress Disorder (PTSD): A Systematic Review

Psychiatry and Clinical Psychopharmacology
Background: Posttraumatic stress disorder (PTSD) is a severe, often difficult-to-treat condition, highlighting the need for innovative therapies. Interventional treatments, including neuromodulation, rapid-acting pharmacotherapies such as intravenous ...
Reinhard Janssen-Aguilar, Shakila Meshkat, Huda F. Al-Shamali, Argyrios Perivolaris, Jennifer Swainson, Yanbo Zhang, Andrew Greenshaw, Lisa Burback, Olga Winkler, Jennifer L. Phillips, Murray W. Enns, Jitender Sareen, Andrew Nicholson, Eric Vermetten, Rakesh Jetly, Ruth Lanius, Venkat Bhat   +16 more
doaj   +1 more source

Diagnosis of the phenomenon of cognitive-motor dissociation in patients with chronic consciousness disorders

Неврология, нейропсихиатрия, психосоматика, 2019
Locked-in syndrome in basilar artery thrombosis is a classic example of dissociation between preserved consciousness and complete deefferentation as total myoplegia with preserved vertical eye movement.
V. A. Belkin, D. G. Pozdnyakov, A. A. Belkin   +2 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Programme TMS-EPID-ERGO-ACTION: Rapport de fin de projet

, 2012
« Etude prospective des TMS : déterminants professionnels et facteurs pronostiques des TMSdes membres supérieurs» (équipe responsable : Laboratoire d’ergonomie et d’épidémiologieen santé au travail, Angers) et Evaluation de la valeur diagnostique des ...
Roquelaure, Yves, Daniellou, François, Coutarel, Fabien   +2 more
core   +6 more sources

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source