Multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth, Manduca sexta. [PDF]
Manduca sexta, known as the tobacco hornworm or Carolina sphinx moth, is a lepidopteran insect that is used extensively as a model system for research in insect biochemistry, physiology, neurobiology, development, and immunity.
Kanost MR +113 more
europepmc +3 more sources
Tobacco Hornworm Manduca sexta (Linnaeus) (Insecta: Lepidoptera: Sphingidae) [PDF]
The tobacco hornworm, Manduca sexta (L.), is a common pest of plants in the family Solanaceae, which includes tobacco, tomato, pepper, eggplant, and various ornamentals and weeds (del Campo and Renwick 1999).
Morgan A. Byron +1 more
doaj +8 more sources
The Manduca sexta serpinome: Analysis of serpin genes and proteins in the tobacco hornworm. [PDF]
Members of the serpin superfamily of proteins occur in animals, plants, bacteria, archaea and some viruses. They adopt a variety of physiological functions, including regulation of immune system, modulation of apoptosis, hormone transport and acting as ...
Li M +6 more
europepmc +2 more sources
Co-expression of Dorsal and Rel2 Negatively Regulates Antimicrobial Peptide Expression in the Tobacco Hornworm Manduca sexta. [PDF]
Nuclear factor κB (NF-κB) plays an essential role in regulation of innate immunity. In mammals, NF-κB factors can form homodimers and heterodimers to activate gene expression.
Zhong X +5 more
europepmc +2 more sources
Immune Defense Varies within an Instar in the Tobacco Hornworm, Manduca sexta. [PDF]
Research on how insect immunity changes with age as insects develop within an instar, or larval developmental stage, is limited and contradictory. Insects within an instar are preparing for the next developmental stage, which may involve changes in ...
Booth K +3 more
europepmc +2 more sources
Annotation and expression analysis of cuticular proteins from the tobacco hornworm, Manduca sexta. [PDF]
The insect cuticle is a unique material that covers the exterior of the animal as well as lining the foregut, hindgut, and tracheae. It offers protection from predators and desiccation, defines body shape, and serves as an attachment site for internal ...
Dittmer NT +5 more
europepmc +2 more sources
Serine Protease Networks Mediate Immune Responses in Extra-Embryonic Tissues of Eggs in the Tobacco Hornworm, Manduca sexta [PDF]
The melanization and Toll pathways, regulated by a network of serine proteases and noncatalytic serine protease homologs (SPHs), have been investigated mostly in adult and larval insects. However, how these innate immune reactions are regulated in insect
Tisheng Shan +4 more
doaj +2 more sources
Tobacco Hornworm (Manduca sexta) caterpillars as a novel host model for the study of fungal virulence and drug efficacy [PDF]
The two leading yeast pathogens of humans, Candida albicans and Cryptococcus neoformans, cause systemic infections in >1.4 million patients worldwide with mortality rates approaching 75%.
Naomi Lyons +7 more
doaj +2 more sources
Standardized methods for rearing a moth larva, Manduca sexta, in a laboratory setting. [PDF]
The larval tobacco hornworm, Manduca sexta, has been used in a laboratory setting for physiological studies and for pathogen virulence studies. This moth offers a much larger size than the commonly used wax moth (Galleria mellonella), and it can thus be ...
Emma K Spencer +2 more
doaj +2 more sources
Supply-side constraints are insufficient to explain the ontogenetic scaling of metabolic rate in the tobacco Hornworm, Manduca sexta. [PDF]
Explanations for the hypoallometric scaling of metabolic rate through ontogeny generally fall into two categories: supply-side constraints on delivery of oxygen, or decreased mass-specific intrinsic demand for oxygen.
Callier V, Nijhout HF.
europepmc +2 more sources

