Results 241 to 250 of about 564,228 (347)

Sustainability in Analytical Chemistry Illustrated by Pharmaceutical Nitrosamine Testing

open access: yesELECTROPHORESIS, EarlyView.
ABSTRACT Following the valsartan scandal in 2018, the testing of drug substances and drug products for N‐nitrosamines has become a critical and mandatory quality control measure. The European Pharmacopoeia chapter 2.5.42 currently describes three analytical methods for this purpose: HPLC–MS/MS, GC–MS, and GC–MS/MS.
Felix Bredendiek   +2 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

open access: yesEnvironmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons   +17 more
wiley   +1 more source

Perceptions of prevention and cessation ads among US youth who use multiple tobacco products: A qualitative study. [PDF]

open access: yesNicotine Tob Res
Clark SA   +7 more
europepmc   +1 more source

Late‐onset unexplained epilepsy as a risk factor for cognitive impairment and dementia: Protocol for a multi‐center prospective longitudinal observational study (ELUCID)

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Late‐onset unexplained epilepsy (LoUE), defined as epilepsy onset after age 55 without an obvious cause, is an important risk factor for dementia. Studies have shown that 10%–25% of individuals with LoUE develop dementia within 3–4 years following their first seizure.
Alice D. Lam   +13 more
wiley   +1 more source

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