Results 241 to 250 of about 1,070,434 (330)

Effects of High‐ and Low‐Fat Meals on the Bioavailability and Pharmacokinetics of Votoplam, a HTT Gene Splicing Modifier

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Votoplam is a novel, orally bioavailable, small molecule HTT gene splicing modifier that is being developed for the treatment of Huntington's disease. This was a single dose, open‐label, two‐period, crossover food effect study that evaluated the effect of high‐ and low‐fat meals on 20 mg votoplam in healthy participants. There was a washout of
Lucy Lee, Amy‐Lee Richards, Nageswara Reddy, Brian Beers, Lee Golden, Ronald Kong   +5 more
wiley   +1 more source

Religiosity, school connectedness, and tobacco use susceptibility: a longitudinal study of adolescents in Mumbai and Kolkata, India. [PDF]

BMC Public Health
McCarthy WJ, Mistry R, Puntambekar NK, Raghunathan T, Kleinsasser MJ, Desai MB, Gupta PC, Pednekar MS.   +7 more
europepmc   +1 more source

A Phase 1, Randomized, Placebo‐Controlled, Multiple‐Dose, Double‐Blind Study to Evaluate and Compare the Pharmacokinetics and Safety of Rimegepant in Healthy Adult Japanese and Caucasian Individuals

Clinical Pharmacology in Drug Development, EarlyView.
Abstract This Phase 1, randomized, placebo‐controlled, double‐blind study assessed the pharmacokinetic profile of rimegepant (25, 75, or 150 mg once daily for 14 days) in healthy Japanese and Caucasian adults. Exposures were modestly increased in Japanese participants compared with Caucasian participants following a single dose of rimegepant (Day 1 ...
Rajinder Bhardwaj, Chay Ngee Lim, Yinhua Li, Kyle T. Matschke, Richard Bertz, Robert Croop, Jing Liu   +6 more
wiley   +1 more source

The Cultural Tapestry of Tobacco Use in India: A Narrative Review. [PDF]

Cureus
More S, Sachdev SS, Bareen N, Mistry LN, Patil A, Patil T.   +5 more
europepmc   +1 more source

Vaporized Nicotine (E-Cigarette) and Tobacco Smoking among People with HIV: Use Patterns and Associations with Depression and Panic Symptoms

Andrew W. Hahn, S Ruderman, R.M Nance, Bill Whitney, S Eltonsy, L Haidar, J.A.C Delaney, Lydia N. Drumright, Jun Ma, K.H Mayer, Conall O. 'Cleirigh, Sonia Napravnik, Joe Eron, Katerina Christopoulos, Laura Bamford, Edward R. Cachay, Jeff Jacobson, Amanda L. Willig, K Cropsey, Geetanjali Chander, H.M Crane, R.J Fredericksen   +21 more
openalex   +1 more source

Interventions for tobacco use prevention in Indigenous youth

, 2012
Kristin Carson‐Chahhoud, Malcolm P Brinn, Nadina A Labiszewski, Matthew Peters, Anne B. Chang, Antony Veale, Adrian Esterman, Brian J Smith   +7 more
openalex   +2 more sources

Charge State Influence on Stability and Isomerism in Dehydrogenated PAHs: Insights from Anthracene, Acridine, and Phenazine

ChemPhysChem, Volume 26, Issue 6, March 15, 2025.
The ionization of anthracene, acridine, and phenazine has been explored, along with the removal of one and two hydrogen atoms, to provide valuable information for astrochemists and to understand the behavior of the resulting structures and their electronic reorganization. Abstract In this study, we systematically explored the stability and isomerism of
Khaldia Zghida, Farouk Hamza Reguig, Manuel Alcamí, Al Mokhtar Lamsabhi   +3 more
wiley   +1 more source

Trends in global research on tobacco use among sexual and gender minorities: A bibliometric analysis, 1984-2024. [PDF]

Tob Induc Dis
Qiu L, Shirui Z, Luo M.
europepmc   +1 more source

The use of edaphic factors to map the spatial distribution of root knot nematodes in tobacco plantations

, 2013
R. T. Muzh, Cleopas C. Chinheya, Pepukai Manjeru, S. Dimbi   +3 more
openalex   +2 more sources

Dietary‐Driven Gene Expansion

Clinical Pharmacology &Therapeutics, EarlyView.
Gene duplication has been shown to drive molecular evolution, with dietary pressures expanding detoxification genes across species. In humans, CYP2D6 gene duplications enhance alkaloid and drug metabolism, reflecting ancient dietary adaptations. Similarly, tobacco‐feeding aphids amplify CYP6CY3 for nicotine and insecticide resistance, and as recently ...
Magnus Ingelman‐Sundberg
wiley   +1 more source