Results 61 to 70 of about 51,916,239 (385)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Associations between childbirth, gang exposure and substance use among young women in Cape Town, South Africa

Substance Abuse Treatment, Prevention, and Policy
The prevalence and influence of gangs on adolescents and young adults remain a concern in Western Cape, South Africa—particularly as they have one of the largest gang presence.
Felicia A. Browne, Tara Carney, Bronwyn Myers, Courtney Peasant Bonner, Wendee M. Wechsberg   +4 more
doaj   +1 more source

Disparities in Tobacco Smoking by Sex and Employment Status: Results from South Africa’s First Global Adult Tobacco Survey

Social Sciences
Background/Objectives: Tobacco smoking is a cause of premature death and illness globally. This study examined the prevalence and factors associated with tobacco smoking among South African adults according to sex, education, and employment status among ...
Catherine O. Egbe, Portia Nevhungoni, Mukhethwa Londani   +2 more
doaj   +1 more source

COVID-19 Vaccination Uptake and Hesitancy Among Current Tobacco Users

Tobacco Use Insights, 2021
Novel mRNA vaccines have been developed and were first distributed to high-risk individuals (including smokers) in the United States starting in December 2020 to combat the coronavirus (COVID-19) pandemic. Over one-half of the U.S.
Nicolle M Krebs, Gail D’Souza, Candace Bordner, Sophia I Allen, Andrea L Hobkirk, Jonathan Foulds, Jessica M Yingst   +6 more
doaj   +1 more source

The Use and Abuse of Tobacco [PDF]

The American Journal of the Medical Sciences
From the 8th Edinburgh ed. ; xi, 138 p.
openaire   +2 more sources

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

KNOWLEDGE AND PRACTICES OF TOBACCO USE AND ITS CONTROL AMONG TOBACCO CONSUMERS IN SELECTED AREAS

Indian Journal of Psychiatric Nursing, 2014
Tobacco use is the leading preventable cause of death and more than five million people die globally from the effects of tobacco use every year. Every eight seconds someone, somewhere in the world dies as a result of tobacco use related complications. It
Pramod V Kademani, Sateesh Sindhe, Shireesh S Shindhe, V. Savitha, Nagarajaiah   +4 more
doaj   +1 more source

Country Participation in the WHO Framework Convention on Tobacco Control Health Warnings Database

Tobacco Use Insights, 2021
Background The World Health Organization’s (WHO) Framework Convention on Tobacco Control (FCTC) Health Warnings Database is an online, publicly available resource created for countries to upload and share pictorial health warnings for tobacco packaging ...
Christopher M. Seitz, Kenneth D. Ward, Zubair Kabir   +2 more
doaj   +1 more source

Prevalence, Reasons for Use, and Risk Perception of Electronic Cigarettes among Post-Acute Coronary Syndrome Smokers [PDF]

, 2016
Purpose—The use of electronic cigarettes (e-cigarettes) has risen dramatically in recent years. However, there is currently no published data on use of e-cigarettes among cardiac patients. The current study reports on the prevalence, reasons for use, and
Busch, Andrew M., Tooley, Erin M.
core   +2 more sources

The Use of Tobacco by Boys [PDF]

The Boston Medical and Surgical Journal, 1884
n ...
openaire   +2 more sources