Results 61 to 70 of about 362,387 (260)

CLIMATRIAL: applicability and adaptability of a novel method to quantify the carbon footprint of a South African clinical trial

Trials
Background No formal assessment of a method to measure the carbon emissions from a clinical trial has been undertaken in the low- and middle-income country setting. We aimed to evaluate the UK-based National Institute of Health Research (NIHR) method for
Nandi Louise Siegfried, Lesley-Ann Erasmus-Claassen, Jessica Griffiths, Lisa Fox, Paula R. Williamson   +4 more
doaj   +1 more source

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

Restoration of continuous cropping obstacles by microbial inoculants and mineral amendment in flue-cured tobacco

Industrial Crops and Products
Continuous cropping obstacles (CCOs) impair soil health and reduce crop yields, posing a significant challenge to agricultural sustainability. Tobacco is a vital economic crop worldwide.
Chen Wang, Qi Miao, Yong Zhang, Lu Liu, Juan Li, Guoming Zhao, Yanming Yang, Kun Huang, Mingzhen Xing, Youtao Ning, Zhenling Cui, Junwei Sun, Yanbin Guo   +12 more
doaj   +1 more source

Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

Advanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang, Dongzhi Wang, Yafei Guo, Qi Zheng, Min Zhang, James Simmonds, Jian Hou, Xuemei Liu, Xuelei Lin, Xiaomin Bie, Xiansheng Zhang, Xiaohui Li, Yuan Chen, Xueyong Zhang, Cristobal Uauy, Fei Lu, Chengcai Chu, Zhixi Tian, Jun Xiao   +18 more
wiley   +1 more source

Construction of a mutant library associated with aroma genes in tobacco using CRISPR/Cas9

Guangxi Zhiwu
To explore the feasibility of constructing a tobacco mutant library using the CRISPR/Cas9 gene editing technology, we designed sgRNAs of 100 aroma related genes in tobacco, constructed a plasmid library composed of 100 corresponding CRISPR/Cas9 editing ...
ZENG Wanli1, LIANG Gang2, GAO Qian1, LI Yuanchuan3, XU Li1, JIANG Jiarui1, XU Yong1, XIANG Haiying1*
doaj   +1 more source

Developing a Guided Imagery Telephone-Based Tobacco Cessation Program for a Randomized Controlled Trial

Tobacco Use Insights, 2020
Background/Aims: Guided imagery is an evidence-based, multi-sensory, cognitive process that can be used to increase motivation and achieve a desired behavior.
Julie S Armin, Uma Nair, Peter Giacobbi, Gayle Povis, Yessenya Barraza, Judith S Gordon   +5 more
doaj   +1 more source

A Virus‐Inducible E3–RLCK–MADS Module Coordinates Suppression of Plant Immunity and Fertility in Rice

Advanced Science, EarlyView.
ABSTRACT Viruses often hijack host developmental programs to promote infection, but the mechanistic links between reproductive regulation and antiviral immunity remain incompletely understood. Here, we identify a virus‐triggered hierarchical degradation cascade that links antiviral immunity and fertility regulation in rice. We show that the rice grassy
Yuansheng Wu, Fengling Wu, Shiting Huang, Denglu Yang, Xin Lei, Xue Zhang, Na Liu, Peng Gan, Chuan Li, Jie Zhang, Ming Wu, Qingxiao Jia, Shanshan Zhao, Jianguo Wu   +13 more
wiley   +1 more source

Psychosocial and Behavioral Characteristics among Subgroups of Nondaily College Student Smokers

Tobacco Use Insights, 2014
Nondaily smoking is becoming common in young adults and there appear to be different characteristics associated with past month smoking frequency among nondaily smokers.
Devan R. Romero, Kim Pulvers, Taneisha S. Scheuermann, Jasjit S. Ahluwalia   +3 more
doaj   +1 more source

Perceptions and Use of Electronic Nicotine Delivery Systems Among Floridian Middle and High School Students: Secondary Analysis of Cross-sectional Survey Results

Tobacco Use Insights, 2020
Introduction: Rapid increase in youth use of Electronic Nicotine Delivery Systems (ENDS) led the state and the federal governments to implement minimum-age policies to restrict minors’ access to vaping products.
Anastasiya Ferrell, Linda Hadddad, Jennifer Harrison Elder, Cyndi Garvan, Christa L Cook, Ramzi Salloum   +5 more
doaj   +1 more source

SERRATE Regulates Floral Meristem Activity by Antagonizing SHOOT MERISTEMLESS and Repressing Cytokinin Signaling

Advanced Science, EarlyView.
Floral meristem (FM) activity is crucial for the initiation of floral organs. In this study, SE represses IPT7 expression and cytokinin signaling via both the miR171c‐5p–KNAT2 and miR164c–CUC1/2–KNAT2 regulatory modules, thereby repressing FM activity. In contrast, STM induces both KNAT2 and IPT7 expression.
Wen Yang, Yiting Wang, Yuxin You, Zhiyue Wu, Dongbao Li, Xin Wang, Yongsheng Chang, Hang Zhao, Tao Zhu, Dijun Chen, Wei Chen, Bo Sun   +11 more
wiley   +1 more source