Results 91 to 100 of about 208,912 (300)
Advanced Science, EarlyView.Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li +13 more
wiley +1 more source
The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos
Advanced Science, EarlyView.Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan +8 more
wiley +1 more source
Clinical Epidemiology and Global HealthBackground: Tobacco dependence among patients with Tuberculosis (TB)(confirmed through microbiological tests) can have detrimental effects on treatment outcomes and immune responses. The study is aimed at assessing the prevalence of self-reported tobacco
Ankeeta Menona Jacob +2 more
doaj +1 more source
Advanced Science, EarlyView.Floral meristem (FM) activity is crucial for the initiation of floral organs. In this study, SE represses IPT7 expression and cytokinin signaling via both the miR171c‐5p–KNAT2 and miR164c–CUC1/2–KNAT2 regulatory modules, thereby repressing FM activity. In contrast, STM induces both KNAT2 and IPT7 expression.
Wen Yang +11 more
wiley +1 more source
Barriers to Smoking Cessation in Patients Enrolled in Suboxone Treatment Programs [PDF]
, 2019 Cigarette smoking is the leading cause of preventable death and disease in the United States, accounting for more than 480,000 deaths every year. The prevalence of tobacco use among substance abuse treatment program enrollees is substantially higher than
Arnell, Thomas L
core +1 more source
Annals of Gastroenterological Surgery, EarlyView.Alcohol relapse after liver transplantation is difficult to predict using abstinence duration alone. We developed a multifactor model integrating abstinence duration, psychosocial risk (SIPAT), and socioeconomic context (AUC 0.70). This approach may support individualized risk assessment and tailored follow‐up intensity; external validation is needed ...
Ayato Obana +9 more
wiley +1 more source
Chronic Stress, 2018 Background Stress contributes to the development and maintenance of substance use disorders, with some research suggesting that the impact of stress on substance use disorders is greater in women.
Terril L. Verplaetse +7 more
doaj +1 more source
Effectiveness of a web platform on university students’ motivation to quit smoking
Revista Latino-Americana de Enfermagem, 2020 Objective: to know the dependence on nicotine and the motivation to quit smoking in Nursing and Physiotherapy students of a university in the South of Spain, and to evaluate the impact of an intervention based on the use of information technologies on ...
Alba María Romero-López +2 more
doaj +3 more sources
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT In epidemiological studies, obsessive‐compulsive disorder (OCD) is robustly associated with increased risk of cardiometabolic disorders, including cardiovascular diseases, type 2 diabetes, and obesity. However, the mechanisms behind these associations are unclear. We conducted genetic correlation analyses to explore shared genetic etiology and
Robyn E. Wootton +217 more
wiley +1 more source
Prevalence and variables associated with alcohol and tobacco consumption in burned patients
Archivo Médico de Camagüey, 2020 Background: current studies have showed that there is a high prevalence of alcohol and tobacco use in burned patients. In Cuba, published research on this topic is scarce.
Malvin Rodríguez-Vargas
doaj