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A singleton pregnancy with placental chorioangioma and hydrops fetalis complicated with mirror syndrome and ritodrine-induced side effects: a case report. [PDF]
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Pharmacokinetics of Tocolytic Agents
Clinical Pharmacokinetics, 2004Tocolytic agents are drugs designed to inhibit contractions of myometrial smooth muscle cells. Such an effect has been demonstrated in vitro or in vivo for several pharmacological agents, including beta-adrenergic agonists, calcium channel antagonists, oxytocin antagonists, NSAIDs and magnesium sulfate. However, the aim of tocolysis is not only to stop
Vassilis, Tsatsaris +2 more
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European Clinics in Obstetrics and Gynaecology, 2005
Prematurity has not decreased significantly over the past 20 years, whereas early prematurity has increased. New tocolytic agents have been developed that are increasingly successful at preventing preterm delivery, and that have improved maternal tolerance.
Georges Abitayeh +3 more
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Prematurity has not decreased significantly over the past 20 years, whereas early prematurity has increased. New tocolytic agents have been developed that are increasingly successful at preventing preterm delivery, and that have improved maternal tolerance.
Georges Abitayeh +3 more
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Prostaglandin inhibitors as tocolytic agents
Seminars in Perinatology, 2001Indomethacin, a nonspecific prostaglandin synthetase inhibitor, gained popularity several decades ago as a potent tocolytic agent. This popularity, however, was tempered by concerns over fetal and neonatal complications associated with its use. However, with better recognition of the safety limitations, there has been a renewed interest in using ...
S T, Vermillion, C N, Landen
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Magnesium sulfate as a tocolytic agent
Seminars in Perinatology, 2001Although magnesium sulfate is widely used as a tocolytic agent in the hope of preventing spontaneous preterm birth, there is a paucity of data from large well-designed randomized clinical studies demonstrating the efficacy of magnesium sulfate therapy. Given the potential for untoward side effects and the inherent risks of magnesium sulfate therapy, a ...
P S, Ramsey, D J, Rouse
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Leptin – A tocolytic agent for the future?
Medical Hypotheses, 2010Leptin - a protein hormone is synthesised in the adipose tissue in humans. Its level therefore should be directly proportional to the amount of adipose tissue in the body. When biopsies of human myometrium from obese women were exposed to leptin, it showed a cumulative inhibitory effect on spontaneous as well as induced contractions.
Rekha, Wuntakal, Tony, Hollingworth
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Pharmacology of Tocolytic Agents
Clinics in Obstetrics and Gynaecology, 1984Various drugs have been used to inhibit preterm labour. Selective beta-receptor agonists are the drugs of choice and have been extensively studied for more than ten years. Several controlled studies have demonstrated a significant prolongation of the pregnancy after treatment with beta-receptor agonists and some have demonstrated improved fetal outcome.
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Thermic Effects of Tocolytic Agents
Obstetric Anesthesia Digest, 1987The effect of the tocolytic agents terbutaline and magnesium sulfate on patients' temperatures was examined. Fifty-two women admitted for preterm labor were randomized to a treatment protocol for one of the two agents. Oral temperatures were measured initially and every two hours during treatment. There was no significant difference between the initial
M T, Parsons, C A, Owens, W N, Spellacy
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Evidence for Magnesium Sulfate as a Tocolytic Agent
Obstetrical & Gynecological Survey, 1997The objective of our study is to quantitatively examine the available evidence regarding the efficacy and side effects of magnesium sulfate for acute tocolysis (from randomized trials) compared with placebo and beta-agonist agents. Randomized trials comparing magnesium sulfate with placebo or beta-agonists for tocolysis were identified with a MEDLINE ...
G A, Macones +4 more
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