Results 41 to 50 of about 282,804 (267)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Morphology, Transport, and Dynamics of Protein Adsorption in Open‐Cell Metal Foam

Advanced Engineering Materials, EarlyView.
Stainless steel (SS) open‐cell foams are shown to adsorb more protein per unit area than previously reported 316L SS and chromium oxide surfaces under static and flow conditions. An integrated approach combining 3D pore imaging, flow simulation, and protein adsorption experiments characterizes the foam’s performance.
Chinmaya Prerana Inguva, Joseph Lavoie, Afsaneh Rabiei   +2 more
wiley   +1 more source

Cryogenic Deformation Behavior of TiAl and Insights Into Embrittlement After High‐Temperature Exposure Combined With Secondary Ion Mass Spectroscopy of Near Surface Chemistry

Advanced Engineering Materials, EarlyView.
Near‐surface deuterium enrichment profiles for different microstructural types of TiAl after exposure at 700 °C in a heavy water‐containing environment. The deuterium levels are significantly higher than expected from natural occurrence, indicating that the heavy water dissociated during the exposure treatment and entered the specimens.
Jonathan D. H. Paul, Alexander Welle, Dirk Matthiessen, Michael Oehring, Fritz Appel, Florian Pyczak   +5 more
wiley   +1 more source

Impact of Various Image Reconstruction Methods on Joint Compensation of Respiratory Motion and Partial Volume Effects in Whole-Body 18F-FDG PET/CT Imaging: Patients with Non-Small Cell Lung Cancer

Iranian South Medical Journal, 2022
Background: The present study aims to assess the impact of various image reconstruction methods in 18F-FDG PET/CT imaging on the quantification performance of the proposed technique for joint compensation of respiratory motion and partial volume effects (
Pardis Ghafarian, Sahar Rezaei, Esmaeil Gharepapagh, Saeid Sarkar, Mohammad Reza Ay   +4 more
doaj  

Visualisation of lenticulostriate arteries using contrast-enhanced time-of-flight magnetic resonance angiography at 7 Tesla

Scientific Reports, 2022
7 Tesla-field-strength (7 T) Magnetic Resonance Imaging allows the small perforating arteries in the brain to be visualised, and this modality may allow visualisation of the arterial pathology in cerebral small vessel disease.
Christopher N. Osuafor, Catarina Rua, Andrew D. Mackinnon, Marco Egle, Philip Benjamin, Daniel J. Tozer, Christopher T. Rodgers, Hugh S. Markus   +7 more
doaj   +1 more source

Secondary metabolites identified in Trichoderma strains using UPLC-ESI-Q-TOF-MS.

, 2022
Secondary metabolites identified in Trichoderma strains using UPLC-ESI-Q-TOF-MS.
Andreia M. Porcari (5093840), Estefenson Marques Morais (12422519), Francisca Diana da Silva Araújo (12422537), Alex Ap. Rosini Silva (11331731), Caroline Pais de Carvalho (12422534), Francisco Wderson Araújo de Sousa (12422522), Helane França Silva (5083772), Izabelle Maria Barboza de Azevedo (12422525), Alice Maria Gonçalves Santos (12422528), José Evando Aguiar Beserra Júnior (12422531), Marcos Nogueira Eberlin (607225)   +10 more
core   +1 more source

Biomineral‐Inspired Organic/Inorganic Colloidal Liquid‐Crystalline Hybrids for Photoresponsive Adhesion

Advanced Functional Materials, EarlyView.
A new class of photoresponsive liquid‐crystalline (LC) adhesives based on biomineral‐inspired organic/inorganic colloidal hybrids is reported. These colloidal LC materials are formed by hybridization of a hydroxyapatite nanorod with azobenzene‐based forklike molecules.
Junya Uchida, Ryuta Kiguchi, Riki Kato, Yuta Nishina, Takashi Kato   +4 more
wiley   +1 more source

Characterization of the chemical constituents in ELP by UPLC-Q-TOF-MS.

, 2022
Characterization of the chemical constituents in ELP by UPLC-Q-TOF-MS.
Yi Zhang (9093), Chuan Liu (367528), Ya Tu (10836785), Jinsong Su (12055152), Fangfang Fan (312738), Lu Zhong (5277710)   +5 more
core   +1 more source

Simultaneous Enhancement of Performance and Stability in Dual‐Gate a‐IGZO Thin‐Film Transistors via Single‐Step Laser Annealing for Capacitor‐Less DRAM

Advanced Functional Materials, EarlyView.
A single‐step laser annealing strategy is presented for dual‐gate a‐IGZO TFTs. The steep thermal gradient induces graded oxygen doping in the channel and simultaneous WOx removal at the contacts, enabling concurrent interface and contact engineering.
Sihyeon Kwon, Junil Kim, Geuntae Park, Minseok Kim, Woohyun Hwang, Wanki Kim, Daewon Ha, Byeongmoon Lee, Jae Eun Jang, Hyuk‐Jun Kwon   +9 more
wiley   +1 more source

Tetralogy of Fallot with Sepsis Induced Coagulopathy in Case of Spontaneous Intracerebral Haemorrhage & Subarachnoid Haemorrhage

Jurnal Neuroanestesi Indonesia
Congenital heart disease is the most common cause of stroke in some children. A child aged 5 years 9 months came with complaints of decreased consciousness and shortness of breath, weight 23 kg and height 140 cm, blood pressure 140/95 mmHg, pulse 52x ...
Bagas Emas, Achmad Wahib Wahju Winarso, Dewi Yulianti Bisri   +2 more
doaj   +1 more source