Results 51 to 60 of about 54,820 (267)

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Business Processes Modelling of Crowdinvesting Platforms Based on Assets’ Tokenization

Мир новой экономики, 2022
The rapid development of digital platforms, the formation of new business models of interaction between the economics agents, as well as the problem of increasing the efficiency of resources have generated the need to develop new approaches to the ...
E. V. Popov, A. Y. Veretennikova, S. A. Fedoreev   +2 more
doaj   +1 more source

Galactic Token Sliding

SSRN Electronic Journal, 2022
Given a graph $G$ and two independent sets $I_s$ and $I_t$ of size $k$, the independent set reconfiguration problem asks whether there exists a sequence of $k$-sized independent sets $I_s = I_0, I_1, I_2, \ldots, I_\ell = I_t$ such that each independent set is obtained from the previous one using a so-called reconfiguration step.
Bartier, Valentin, Bousquet, Nicolas, Mouawad, Amer   +2 more
openaire   +4 more sources

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Innovating Pharma: Bridging Traditional Acquisition and Emerging Technologies

Blockchain in Healthcare Today
Objectives: The authors explore how large pharmaceutical corporations may integrate emerging decentralized technologies—such as blockchain and decentralized autonomous organizations (DAOs)—within their merger, acquisition and partnership frameworks, and ...
Simone Fantaccini, Laura Grassi, Scott Howell   +2 more
doaj   +1 more source

Design and analysis of enterprise management system framework based on blockchain

网络与信息安全学报, 2019
How to enhance the management of modern enterprises by blockchain technology has attracted more and more attention. ERP (enterprise resource planning) technology combined modern information technology with enterprise production process management, and ...
ZHAO Wei, ZHANG Wenyin, WANG Jiuru, ZHANG Yawei   +2 more
doaj   +1 more source

Adversarial Tokenization

Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers)
Current LLM pipelines account for only one possible tokenization for a given string, ignoring exponentially many alternative tokenizations during training and inference. For example, the standard Llama3 tokenization of penguin is [p,enguin], yet [peng,uin] is another perfectly valid alternative.
Renato Lui Geh, Zilei Shao, Guy Van den Broeck   +2 more
openaire   +3 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Digital technologies in investment activities

E-Management
The issues of development of digital financial technologies in the Russian Federation (hereinafter referred to as RF, Russia) are investigated. The article considers foreign and domestic experience of using digital technologies in financial and ...
V. V. Prokhorov, I. P. Rozhnov
doaj   +1 more source

Separation of circulating tokens [PDF]

Theoretical Computer Science, 2009
Self-stabilizing distributed control is often modeled by token abstractions. A system with a single token may implement mutual exclusion; a system with multiple tokens may ensure that immediate neighbors do not simultaneously enjoy a privilege. For a cyber-physical system, tokens may represent physical objects whose movement is controlled.
K. Ghosh Dastidar, T. Herman
openaire   +3 more sources