Results 51 to 60 of about 1,738,131 (340)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Agent-based model using GPS analysis for infection spread and inhibition mechanism of SARS-CoV-2 in Tokyo

open access: yesScientific Reports, 2022
Analyzing the SARS-CoV-2 pandemic outbreak based on actual data while reflecting the characteristics of the real city provides beneficial information for taking reasonable infection control measures in the future.
Taishu Murakami   +3 more
doaj   +1 more source

Extracted Memory from Temporal Patterns Using Adaptive Resonance and Recurrent Network [PDF]

open access: yes, 1993
We can recognize objects through receiving continuously huge temporal information including redundancy and noise, and can memorize them. This paper proposes a neural network model which extracts pre-recognized patterns from temporally sequential patterns
Araki, Osamu
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

TOKYO

open access: yes, 2018
Abstract Japan has endeavoured to develop its capital Tokyo as one of the top global financial centres. Japan’s advantages are the sheer size of its economy (the third largest in terms of gross domestic product), the status of the Japanese yen as the third international currency after the United States dollar and the euro, and large ...
openaire   +2 more sources

Peripheral Neurolopathy in Xeroderma Pigmentosum

open access: yesPediatric Neurology Briefs, 1990
The peripheral nerve pathology in two autopsied cases of group A xeroderma pigmentosum (De Sanctis Cacchione syndrome) is reported from the Tokyo Medical and Dental University, Tokyo Metropolitan Neurological Hospital, and Tokyo Metropolitan Kita Medical
J Gordon Millichap
doaj   +1 more source

Book review: Sanctuaries of the city: lessons from Tokyo [PDF]

open access: yes, 2013
How do we find calm in dense heaving cities such as Tokyo, London, or New York? In Sanctuaries of the City, Anni Greve explores how places such as market squares, arts venues, and religious sites offer sociospatial capacities that enable the development ...
Litchfield, Rebecca
core  

Supernova Detection via a Network of Neutral Current Spherical TPC's

open access: yes, 2006
The coherent contribution of all neutrons in neutrino nucleus scattering due to the neutral current offers a realistic prospect of detecting supernova neutrinos.
Giomataris, Y., Vergados, J. D.
core   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

open access: yesFEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima   +4 more
wiley   +1 more source

Corpus delicti: From Tōkyō monogatari to Tokyo-Ga

open access: yesRevista de Comunicación, 2017
This essay will deal with the main characteristics of Ozu’s oeuvre, mainly with the interesting relationship that he established with the cinematographic camera. It will be analyzed the way in which his oeuvre deals with the important transformation that
Duarte, G. A.
doaj   +1 more source

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