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Drug tolerability: How much ambiguity can be tolerated? A systematic review of the assessment of tolerability in clinical studies

British Journal of Clinical Pharmacology, 2022
Aims: Drug tolerability refers to the degree to which drugs' overt adverse effects can be tolerated by patients. The tolerability profile is of comparative importance to its efficacy and safety, as it largely determines adherence to treatment and ...
Vid Stanulovic, Papadopoulos D
exaly   +2 more sources

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Rapid tolerance and cross-tolerance as predictors of chronic tolerance and cross-tolerance

Pharmacology Biochemistry and Behavior, 1992
Hypothermia and motor impairment (tilt-plane) tests were used to assess the phenomenon of rapid tolerance to ethanol and cross-tolerance to various alcohols, benzodiazepines, and barbiturates that differ in lipid:water partition coefficients. The hypothermic and motor impairment responses to ethanol were significantly reduced on day 2 in rats receiving
J M, Khanna, H, Kalant, J, Weiner, G, Shah   +3 more
openaire   +2 more sources

Tolerability of Paracetamol*

Drugs, 2003
The excellent tolerability of therapeutic doses of paracetamol (acetaminophen) is a major factor in the very wide use of the drug. The major problem in the use of paracetamol is its hepatotoxicity after an overdose. Hepatotoxicity has also been reported after therapeutic doses, but critical analysis indicates that most patients with alleged toxicity ...
Garry G, Graham, Kieran F, Scott, Richard O, Day   +2 more
openaire   +3 more sources

Tolerance: Toleration

2020
Centuries of political and religious struggle and social advances regarding the ethical-political definition of toleration will be required before civil society can achieve Thomas More's (1478-1535) utopia: namely, a society where no citizen is judged according to religion.
openaire   +2 more sources